68Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake.

Radiologia brasileira
Matheus Zanelatto JunqueiraMarcelo Tatit Sapienza

Abstract

To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy. Ten patients with prostate cancer were submitted to 68Ga-PSMA positron emission tomography/computed tomography with unilateral ECSG. The ECSG was started at 30 min before the injection of the radiotracer and maintained until the end of image acquisition (1 h after injection). Each salivary gland was assessed by determining the maximum, mean, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak, respectively). The volume of each gland was determined in a volume of interest delineated by a threshold SUVmax of 10%. Paired Student's t-tests were used in order to compare the results. In terms of the SUV parameters, there were no statistically significant differences between the cooled and contralateral salivary glands. However, the mean volume was 27% lower in the cooled parotid glands than in the contralateral parotid glands (p = 0.004). The use of ECSG does not appear to reduce 68Ga-PSMA uptake by the salivary glands. In addition, there is...Continue Reading

References

Apr 13, 2004·Journal of Applied Physiology·Seham MustafaH N Ismael
Jun 10, 2006·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Olav Thulesius
Apr 21, 2007·Clinical Physiology and Functional Imaging·S MustafaH N Ismael
Apr 30, 2009·American Journal of Rhinology & Allergy·Yueng-Hsiang ChuHsing-Won Wang
Jun 5, 2012·Urologic Oncology·Joseph R OsborneScott T Tagawa
May 28, 2014·Monographs in Oral Science·Kyle V Holmberg, Matthew P Hoffman
Mar 18, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Clemens KratochwilUwe Haberkorn
Apr 5, 2017·Journal of the National Cancer Institute·Ahmedin JemalHannah K Weir
Feb 14, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David TaïebUwe Haberkorn
Jun 7, 2018·Molecular Imaging·Kambiz RahbarHojjat Ahmadzadehfar
Jun 16, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Thomas LangbeinRichard P Baum
Jul 5, 2018·EJNMMI Research·Ludwike W M van KalmthoutArthur J A T Braat
Feb 10, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Niels J RuppIrene A Burger
Mar 10, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Burcak YilmazTevfik Fikret Çermik

❮ Previous
Next ❯

Software Mentioned

R Commander
OsiriX Dicom Viewer Lite

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecular Imaging and Radionuclide Therapy
Cihan GündoğanTevfik Fikret Çermik
Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
Felipe CouñagoElia Del Cerro
© 2021 Meta ULC. All rights reserved