PMID: 9184316May 31, 1997Paper

6p24-22 region and major psychoses in the Eastern Quebec population. Le Groupe IREP

American Journal of Medical Genetics
M MaziadeC Mérette

Abstract

Recent reports of a linkage trend in 6p24-22 for schizophrenia (SZ), in different samples, were tempered by the concurrent evidence of negative reports in other samples. In the studies showing positive results, different definitions of affection and a wide spectrum of diagnoses were used. Our objectives were not only to test for linkage at 6p24-22 in the Eastern Quebec population, but also to test whether this putative vulnerability locus was either selectively linked to schizophrenia (SZ), or to bipolar disorder (BP), or to both major psychoses. Parametric and nonparametric linkage analyses with 12 microsatellite markers in 6p24-p22 were performed on a sample of 18 large multigenerational pedigrees (N = 354) either affected by SZ, or by BP, or equally affected by both major psychoses (i.e., mixed pedigrees). Three affection definitions were usually tested in our program: one on schizophrenia (SZ), one on bipolar disorder (BP), and one that comprised SZ and BP under the hypothesis of a susceptibility locus common to both in major psychoses (common locus, CL). The results of parametric analyses did not support a major gene hypothesis. However, in one large mixed pedigree (#151), we observed with the common locus phenotype (CL) l...Continue Reading

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Citations

Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·A B Goodman
Oct 30, 2009·Psychiatric Genetics·Lingjun ZuoJoel Gelernter
Dec 14, 2011·BMC Medical Genetics·Ashley J R Carter, Andrew Q Nguyen
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Feb 13, 2002·American Journal of Medical Genetics·Michel MaziadeChantal Mérette
Feb 3, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H Le-NiculescuA B Niculescu
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Jun 9, 2004·Neurotoxicity Research·Brien Riley
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jill M GoldsteinTracey L Petryshen
Mar 20, 2002·Psychiatric Genetics·T Swift-ScanlanM G McInnis
Dec 28, 2017·European Journal of Gastroenterology & Hepatology·Karn WijarnpreechaPatompong Ungprasert

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