7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity

Bioorganic & Medicinal Chemistry Letters
Terry V HughesSteven A Middleton

Abstract

A novel series of 7-[1H-indol-2-yl]-2,3-dihydro-isoindol-1-ones designed to be inhibitors of VEGF-R2 kinase was synthesized and found to potently inhibit VEGF-R2 and Aurora-A kinases. The structure-based design, synthesis, and initial SAR of the series are discussed.

References

Apr 30, 2003·The Journal of Cell Biology·Claire DitchfieldStephen S Taylor

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Citations

Oct 6, 2014·European Journal of Medicinal Chemistry·Irena SovićGrace Karminski-Zamola
Feb 10, 2009·Chembiochem : a European Journal of Chemical Biology·Teresa SardonIsabelle Vernos
May 16, 2009·Expert Opinion on Therapeutic Patents·Mohane Selvaraj CoumarHsing-Pang Hsieh

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