Oct 10, 1977

7 alpha-Hydroxylation of 5 alpha-androstane-3 beta, 17 beta-diol in normal and hyperplastic human prostate

Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D: Sciences naturelles
R F Morfin, H Floch

Abstract

Incubation of 4-14C-5 alpha-androstane-3 beta, 17 beta-diol with human normal and hyperplastic prostate minces led to the NADPH-dependent production of a major polar radiometabolite which was identified as 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol and proved the presence of a 3 beta-hydroxysteroid-7 alpha-hydroxylase in prostate. Such evidences may bring new leads for the study of the mechanisms of androgenic steroid action in the prostate gland.

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Mentioned in this Paper

Androgenic steroid
Epithelioid Hemangioma of Skin
androstane, (5alpha)-isomer
5 beta-Androstane-3 alpha,17 beta-diol
Androstanes
Prostate
Steroid Hydroxylases
NADP
Prostatism
Hyperplasia

About this Paper

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