7-Chloro-4-(Phenylselanyl) Quinoline with Memory Enhancer Action in Aging Rats: Modulation of Neuroplasticity, Acetylcholinesterase Activity, and Cholesterol Levels

Molecular Neurobiology
Anelise BarthCristiane Luchese

Abstract

This study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) to restore the cognitive impairment caused by aging in male Wistar rats. Moreover, modulation of neuroplasticity markers, acetylcholinesterase (AChE) activity, and cholesterol levels was performed. Aged rats were intragastrically treated with 4-PSQ (5 mg/kg) for 7 days. Animals were tested in behavioral tasks, and then plasma (to determine cholesterol levels), hippocampus, and cerebral cortex (to determine neural cell adhesion molecule (NCAM) and polysialyltransferase (PST) levels, and AChE activity) were removed. Our findings demonstrated that treatment of aged rats with 4-PSQ restored short-term and long-term memories in the object recognition tests. 4-PSQ treatment did not restore exploratory activity (rearings) but partially restored locomotor activity (crossings) reduced by aging in the open-field test. Moreover, the compound restored the reduction in the NCAM and PST levels, and AChE activity in cerebral structures, as well as the increase in the plasma cholesterol levels, caused by aging in rats. In conclusion, 4-PSQ restored cognitive impairment caused by aging in rats by modulating synaptic plasticity, cholinergic system, and cholesterol...Continue Reading

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Citations

Aug 19, 2020·Canadian Journal of Physiology and Pharmacology·Briana B LemosEthel A Wilhelm
Mar 20, 2021·Psychopharmacology·Karline C RodriguesCristiane Luchese
Sep 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vedangana SainiGurcharan Kaur
May 21, 2021·Canadian Journal of Physiology and Pharmacology·Ketlyn P da MottaEthel A Wilhelm

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Methods Mentioned

BETA
nuclear magnetic resonance
PCR

Software Mentioned

Stratagene MxPro
Graphpad Prism®

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