7-Isopenthenyloxycoumarin, Arctigenin, and Hesperidin Modify Myeloid Cell Leukemia Type-1 (Mcl-1) Gene Expression by Hormesis in K562 Cell Line

Dose-response : a Publication of International Hormesis Society
Zahra KafiOmid Gholami

Abstract

Hormesis is a new concept in dose-response relationship. Despite of traditional dose-response curves, there is a low-dose stimulation and a high-dose inhibition in this case. Hormesis effect in apoptosis induction/inhibition by natural compounds is reported previously. Here, we searched this effect for myeloid cell leukemia type-1 (Mcl-1) gene expression by phytochemicals 7-isopenthenyloxycoumarin (7-IP), arctigenin (Arg), and hesperidin (Hsp). For this purpose, first we tested the cytotoxicity of various doses of these compounds against K562 leukemia cell lines for different times by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. After that we explored the effect of various doses of these phytochemicals on Mcl-1 gene expression for different times by real-time polymerase chain reaction method. We found that these phytochemicals have cytotoxicity against K562 cell line. Hesperidin is the most cytotoxic agent. We also found that these natural compounds have hormetic effect on Mcl-1 gene expression. The hormetic model in Mcl-1 gene expression is overcompensation stimulation. This phenomenon is reported for the first time. We conclude that 7-IP, Arg, and Hsp are cytotoxic against K562 cancerous cells and indu...Continue Reading

References

Sep 25, 2003·Biochemical Pharmacology·Yen-Chou ChenHui-Yi Lin
Nov 17, 2006·Environmental Health Perspectives·Ralph Cook, Edward J Calabrese
Apr 2, 2010·Journal of Natural Products·Guy LewinThierry Cresteil
May 25, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Seied Mojtaba ValiahdiAmirhossein Sahebkar
Jul 24, 2013·Critical Reviews in Toxicology·Edward J Calabrese
Jan 8, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Fereshteh HaghighiAzadeh Haghighitalab
Feb 15, 2014·Oncotarget·Christian Billard
Apr 11, 2015·Cellular Oncology (Dordrecht)·Zeynep Birsu CincinBedia Cakmakoglu
Apr 15, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Edward J Calabrese
Apr 15, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Edward J Calabrese
Jul 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ratana BanjerdpongchaiPrachya Kongtawelert
Dec 8, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Karin BrechtMarianne Uteng
Jan 18, 2017·Pest Management Science·Ivana Pfs BritoEdivaldo D Velini
Jun 8, 2017·Dose-response : a Publication of International Hormesis Society·Omid Gholami
Sep 28, 2017·Biochemical and Biophysical Research Communications·Yanrui XuSeong-Ho Lee
Oct 25, 2017·Clinical Nutrition Experimental·Piwen WangJaydutt V Vadgama
Jan 26, 2018·Cancer·Moshe TalpazPhilippe Rousselot

❮ Previous
Next ❯

Citations

Mar 12, 2020·Journal of Clinical Medicine·Jadwiga Jodynis-Liebert, Małgorzata Kujawska
Jun 15, 2019·Histochemistry and Cell Biology·Dongmei SuYunjun Zhou
Dec 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesca PreziusoSerena Fiorito

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Prism
SPSS16
GraphPad

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
H D KayR B Herberman
Yao xue xue bao = Acta pharmaceutica Sinica
Miao Yu, Guo Ying
International Journal of Cancer. Journal International Du Cancer
B B Lozzio, C B Lozzio
© 2022 Meta ULC. All rights reserved