Abstract
Hormesis is a new concept in dose-response relationship. Despite of traditional dose-response curves, there is a low-dose stimulation and a high-dose inhibition in this case. Hormesis effect in apoptosis induction/inhibition by natural compounds is reported previously. Here, we searched this effect for myeloid cell leukemia type-1 (Mcl-1) gene expression by phytochemicals 7-isopenthenyloxycoumarin (7-IP), arctigenin (Arg), and hesperidin (Hsp). For this purpose, first we tested the cytotoxicity of various doses of these compounds against K562 leukemia cell lines for different times by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. After that we explored the effect of various doses of these phytochemicals on Mcl-1 gene expression for different times by real-time polymerase chain reaction method. We found that these phytochemicals have cytotoxicity against K562 cell line. Hesperidin is the most cytotoxic agent. We also found that these natural compounds have hormetic effect on Mcl-1 gene expression. The hormetic model in Mcl-1 gene expression is overcompensation stimulation. This phenomenon is reported for the first time. We conclude that 7-IP, Arg, and Hsp are cytotoxic against K562 cancerous cells and indu...Continue Reading
References
Feb 21, 2002·Biological & Pharmaceutical Bulletin·Masaki BabaToru Okuyama
Sep 25, 2003·Biochemical Pharmacology·Yen-Chou ChenHui-Yi Lin
Aug 16, 2005·Environmental Pollution·Edward J Calabrese
Nov 17, 2006·Environmental Health Perspectives·Ralph Cook, Edward J Calabrese
Sep 29, 2009·European Journal of Pharmacology·Mahmoud Zaki El-ReadiMichael Wink
Apr 2, 2010·Journal of Natural Products·Guy LewinThierry Cresteil
Jun 24, 2010·Molecular Cancer Research : MCR·Junya KurodaMasafumi Taniwaki
May 25, 2011·Journal of Cellular Biochemistry·Xiangyang YaoZhimin Yin
May 25, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Seied Mojtaba ValiahdiAmirhossein Sahebkar
Jul 24, 2013·Critical Reviews in Toxicology·Edward J Calabrese
Jan 8, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Fereshteh HaghighiAzadeh Haghighitalab
Feb 15, 2014·Oncotarget·Christian Billard
Apr 11, 2015·Cellular Oncology (Dordrecht)·Zeynep Birsu CincinBedia Cakmakoglu
Apr 15, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Edward J Calabrese
Apr 15, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Edward J Calabrese
Jul 8, 2015·Journal of Cancer Research and Therapeutics·Urja N DesaiRakesh M Rawal
Jul 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ratana BanjerdpongchaiPrachya Kongtawelert
Nov 20, 2015·Phytotherapy Research : PTR·Milad IranshahyMehrdad Iranshahi
Nov 12, 2016·Redox Biology·Chao ZhangChengwei He
Dec 8, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Karin BrechtMarianne Uteng
Jan 18, 2017·Pest Management Science·Ivana Pfs BritoEdivaldo D Velini
Jan 23, 2017·European Journal of Medicinal Chemistry·Alessandra BisiSilvia Gobbi
Jun 8, 2017·Dose-response : a Publication of International Hormesis Society·Omid Gholami
Sep 28, 2017·Biochemical and Biophysical Research Communications·Yanrui XuSeong-Ho Lee
Oct 25, 2017·Clinical Nutrition Experimental·Piwen WangJaydutt V Vadgama
Jan 26, 2018·Cancer·Moshe TalpazPhilippe Rousselot
Feb 21, 2018·Scientific Reports·Enbo CaiShumei Tu
Citations
Mar 12, 2020·Journal of Clinical Medicine·Jadwiga Jodynis-Liebert, Małgorzata Kujawska
Jun 15, 2019·Histochemistry and Cell Biology·Dongmei SuYunjun Zhou
May 16, 2020·Molecular Diversity·Hamid CheshomiMaryam M Matin
Dec 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesca PreziusoSerena Fiorito