7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice

Drug Target Insights
Oguz MutluFaruk Erden

Abstract

Nitric oxide (NO) is an atypical neurotransmitter that causes changes in cognition. Nitric oxide synthase (NOS) and guanylate cyclase (GC) inhibitors have been shown to exert some effects on cognition in previous studies; however, the findings have been controversial. This study was aimed at understanding the effects of an NOS inhibitor, 7-nitroindazole (7-NI), and a guanylate cyclase inhibitor, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), on spatial memory in modified elevated plus maze (mEPM), Morris water maze (MWM), and radial arm maze (RAM) tests. Male Balb-c mice were treated via intraperitoneal injections with 7-NI (15 mg/kg), ODQ (3, 10 mg/kg), L-arginine (100 mg/kg) + 7-NI (15 mg/kg), or physiological saline. ODQ (3 mg/kg) and 7-NI (15 mg/kg) significantly increased the second-day latency in the mEPM test. 7-NI (15 mg/kg) and ODQ (10 mg/kg) significantly increased the escape latency in second, third, and fourth sessions, decreased the time spent in the escape platform's quadrant, and increased the mean distance to the platform in the probe trial of the MWM test. ODQ (3, 10 mg/kg) and 7-NI (15 mg/kg) significantly increased the number of errors, whereas only 7-NI increased the latency in the RAM test. The administ...Continue Reading

References

Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·A C Sharma, S K Kulkarni
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Nov 1, 1993·Neuropharmacology·E Southam, J Garthwaite
Mar 1, 1995·Neurobiology of Learning and Memory·C FinI Izquierdo
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G A BöhmeJ C Blanchard
Feb 1, 1994·Journal of Neurochemistry·R Guevara-GuzmanK M Kendrick
May 1, 1994·Pharmacology, Biochemistry, and Behavior·A BeuzenP Roullet
Dec 1, 1993·Pharmacology, Biochemistry, and Behavior·L B EstallG A Cicala
Jul 1, 1995·British Journal of Pharmacology·K YamadaT Nabeshima
Jul 1, 1996·Japanese Journal of Pharmacology·M ToyodaN Matsuki
Oct 1, 1996·British Journal of Pharmacology·E SouthamJ Garthwaite
May 1, 1997·Pharmacology, Biochemistry, and Behavior·M A PrendergastA V Terry
Mar 28, 1998·Neuropharmacology·G Telegdy, R Kokavszky
May 14, 1998·Neuroscience and Biobehavioral Reviews·D P Cain
Feb 15, 2000·Pharmacology, Biochemistry, and Behavior·F YildizN Gacar
Dec 2, 2000·Behavioural Brain Research·Z Hlinák, I Krejcí
Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
Aug 31, 2001·European Journal of Pharmacology·N PitsikasE E Muller
Feb 15, 2002·Behavioural Brain Research·Zdenek Hlinák, Ivan Krejcí
Jan 1, 1992·The European Journal of Neuroscience·Christelle BonJean-Charles Blanchard
Apr 9, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Abraham J SussweinItay Hurwitz
Aug 18, 2004·Neurochemistry International·Colin J BarnstableMing-Hu Han
Apr 23, 2005·The European Journal of Neuroscience·Wei-Lin ChienWen-Mei Fu
May 2, 2007·Behavioral Neuroscience·Brian C TrainorRandy J Nelson
Jul 2, 2008·European Journal of Pharmacology·Wei-Lin ChienWen-Mei Fu

❮ Previous
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Citations

Feb 2, 2016·International Journal of Pharmaceutics·Muhammad Imran SajidAbdelhamid Elaissari
Feb 15, 2016·Colloids and Surfaces. B, Biointerfaces·Yuwei DuanGuangxi Zhai
Jan 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mina MehannySamar Mansour
Feb 7, 2016·Biochemical and Biophysical Research Communications·Baoming MiMin Yang
Jan 16, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Guido Frosina
Mar 12, 2016·Investigative and Clinical Urology·Vinoth-Kumar Lakshmanan
Nov 28, 2015·International Journal of Pharmaceutics·Kevin Ita
Dec 15, 2015·Drug Discovery Today·Neelesh Kumar Mehra, Srinath Palakurthi
Nov 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Smita K Pawar, Pradeep Vavia
Oct 27, 2015·Biomarkers in Medicine·Igor KoturbashBaitang Ning
Sep 24, 2015·Pharmacology, Biochemistry, and Behavior·Pelin TanyeriBekir Faruk Erden
Nov 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jordan DespanieJ Andrew MacKay
Mar 21, 2016·International Journal of Pharmaceutics·Fatemeh FarjadianSoliman Mohammadi Samani
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming-Li HanYi-Meng Wang
Sep 24, 2015·Expert Opinion on Drug Delivery·Abhijeet D KulkarniChandrakantsing V Pardeshi
Aug 26, 2015·Neurología : publicación oficial de la Sociedad Española de Neurología·D Hernandez-BaltazarA Villanueva-Olivo
May 11, 2016·International Journal of Biological Macromolecules·Fan YangJianxi Xiao
Jul 15, 2016·Journal of Immunotoxicology·Ghasem GhalamfarsaFarhad Jadidi-Niaragh
Sep 3, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chandraiah GoduguMandip Singh
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyMay S Freag
Nov 10, 2016·Ageing Research Reviews·Pu Wang, Zhan-You Wang
Jan 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kevin Ita
Dec 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sonja DragojevicDrazen Raucher
Dec 21, 2019·The International Journal of Neuroscience·Fatemeh MohammadiMohammad Shabani
Oct 20, 2018·Frontiers in Neuroscience·Daniel Moreira-SilvaTatiana L Ferreira
Jan 17, 2021·Pharmaceuticals·Ernesto Fedele, Roberta Ricciarelli
Feb 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Manish Kumar, Nitin Bansal

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