journal cover

7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

Redox Biology

Jan 14, 2020

Sandra GuneschMichael Decker

Abstract

Alzheimer's disease (AD) is a multifactorial disease and the most common form of dementia. There are no treatments to cure, prevent or slow down the progression of the disease. Natural products hold considerable interest for the development of preventive neuroprotectants to treat neurod...read more

Mentioned in this Paper

In Vivo
Laboratory mice
Phenolic acid
Mus
Drug Discovery
Esters
Taxifolin
Slow Disease Progression
Hippocampus (Brain)
Neurotoxicity Syndromes
1
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Alzheimer's Disease: Genes&Microglia

Genes and microglia are associated with the risk of developing and the progression of conditions such as Alzheimer's Disease (AD). Here are the latest discoveries pertaining to this disease.

Microglia: Health and Disease

Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.

Innate Immunity: Neurodegeneration

The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

Microglia And CNS Diseases

Microglia are resident macrophages of the CNS. They play a role in scavenging the CNS for plaques, phagocytosis, and extracellular signaling. Here is the latest research on their role in CNS diseases.

Neurodegeneration: Microglia & TDP-43

TDP43 is is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP43 and microglia in neurodegeneration.

Alzheimer's Disease: Animal models

Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Early Markers

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on early markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

© 2020 Meta ULC. All rights reserved

7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

Redox Biology

Jan 14, 2020

Sandra GuneschMichael Decker

PMID: 31926632

DOI: 10.1016/j.redox.2019.101378

Abstract

Alzheimer's disease (AD) is a multifactorial disease and the most common form of dementia. There are no treatments to cure, prevent or slow down the progression of the disease. Natural products hold considerable interest for the development of preventive neuroprotectants to treat neurod...read more

Mentioned in this Paper

In Vivo
Laboratory mice
Phenolic acid
Mus
Drug Discovery
Esters
Taxifolin
Slow Disease Progression
Hippocampus (Brain)
Neurotoxicity Syndromes
1

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Related Papers

International Journal of Molecular Sciences

Anti-Inflammatory Activity of A Polyphenolic Extract from Arabidopsis thaliana in In Vitro and In Vivo Models of Alzheimer's Disease

International Journal of Molecular SciencesFebruary 10, 2019
Roberto MattioliLuciana Mosca
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/7-o-esters-of-taxifolin-with-pronounced-and/31926632