75Se-methionine platelet survival studies: a proposal for a mathematical correction of the curve

Haemostasis
F FabrisA Girolami

Abstract

We studied platelet survival in 14 cardiac before heart valve replacement using 75Se-methionine 'cohort label'. The temporal variation of plasma and platelet activity was plotted by a continuous curve by means of a computerized interaction of the single points. Then we computed the plasmatic radioactivity fraction used daily for thrombopoiesis and made a subtraction of this aliquot from a experimental activity in the catabolic phase of the slope. Platelet life span obtained after this 'correction' is comparable with the values of random label using 51Cr.

Related Concepts

Blood Platelets
Cell Survival
Heart Valve Prosthesis
Mathematics
Pedameth
Radioisotopes
Selenium

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Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
H J das NevesM P Rocha
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