7,8-Dihydroxyflavone reduces sleep during dark phase and suppresses orexin A but not orexin B in mice

Journal of Psychiatric Research
P FengPhillip J Smith

Abstract

Brain-derived neurotrophic factor (BDNF) binds to Tropomyosin-receptor-kinase B (TrkB) receptors that regulate synaptic strength and plasticity in the mammalian nervous system. 7,8-Dihydroxyflavone (DHF) is a recently identified small molecule Trk B agonist that has been reported to ameliorate depression, attenuate the fear response, improve memory consolidation, and exert neuroprotective effects. Poor and disturbed sleep remains a symptom of major depressive disorder and most current antidepressants affect sleep. Therefore, we conducted sleep/wake recordings and concomitant measurement of brain orexins, endogenous peptides that suppress sleep, in mice for this study. Baseline polysomnograph recording was performed for 24 h followed by treatment with either 5 mg/kg of DHF or vehicle at the beginning of the dark phase. Animals were sacrificed the following day, one hour after the final treatment with DHF. Orexin A and B were quantified using ELISA and radioimmunoassay, respectively. Total sleep was significantly decreased in the DHF group, 4 h after drug administration in the dark phase, when compared with vehicle-treated animals. This difference was due to a significant decrease of non-rapid eye movement sleep, but not rapid ey...Continue Reading

References

Sep 1, 1987·Electroencephalography and Clinical Neurophysiology·I FeinbergJ D March
Dec 1, 1984·Electroencephalography and Clinical Neurophysiology·L S Leung
Dec 1, 1983·The International Journal of Neuroscience·I Gath, E Bar-On
Mar 1, 1997·Psychophysiology·W KlimeschB Ripper
Mar 16, 2000·The EMBO Journal·S G KernieL F Parada
Mar 15, 2002·Neuropsychobiology·Dieter RiemannMathias Berger
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M-F WuJ M Siegel
Aug 29, 2003·Journal of Affective Disorders·Dieter Riemann, Ulrich Voderholzer
Feb 15, 2005·Journal of Affective Disorders·Charles L Bowden
Mar 10, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lena BrundinLil Träskman-Bendz
May 1, 2007·Brain Research·Pingfu FengKingman P Strohl
Oct 20, 2007·International Journal of Clinical Practice·V MaleticJ Russell
Nov 21, 2007·European Journal of Pharmacology·Eric A Stone, Yan Lin
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ugo FaragunaChiara Cirelli
Nov 26, 2008·Neuroscience Letters·Nobuko YamadaKazuwa Nakao
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui YuZhe-Yu Chen
Apr 23, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christian MontagMartin Reuter
Jul 17, 2010·Annals of the New York Academy of Sciences·Takeshi SakuraiNatsuko Tsujino
Jan 5, 2011·Archives of General Psychiatry·Ronald C KesslerT Bedirhan Ustün
Feb 2, 2011·Depression and Anxiety·Nadia IovienoAndrew A Nierenberg
Jul 14, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Owen M WolkowitzSynthia H Mellon
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aurélie BlugeotChrystel Becker
Dec 30, 2011·Sleep & Breathing = Schlaf & Atmung·Angela L McDowellPingfu Feng
Feb 9, 2012·The International Journal of Neuropsychopharmacology·Masahiro SegawaShigeto Yamawaki
Feb 22, 2012·Indian Journal of Psychological Medicine·Ravi Gupta, Vivekananda Lahan
Jun 19, 2012·Sleep Medicine·Anna S UrrilaMauri Marttunen
Feb 13, 2013·Continuum : Lifelong Learning in Neurology·Clifford B Saper

❮ Previous
Next ❯

Citations

Jan 1, 2019·International Journal of Psychiatry in Clinical Practice·Mujgan CengizBurcu Bayoglu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.