7T 1 H-MRS in major depressive disorder: a Ketamine Treatment Study

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Jennifer W EvansCarlos A Zarate

Abstract

The glutamatergic modulator ketamine has striking and rapid antidepressant effects in major depressive disorder (MDD), but its mechanism of action remains unknown. Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive method able to directly measure glutamate levels in vivo; in particular, glutamate and glutamine metabolite concentrations are separable by 1H-MRS at 7T. This double-blind, placebo-controlled, crossover study that included 1H-MRS scans at baseline and at 24 h post ketamine and post-placebo infusions sought to determine glutamate levels in the pregenual anterior cingulate (pgACC) of 20 medication-free MDD subjects and 17 healthy volunteers (HVs) 24 h post ketamine administration, and to evaluate any other measured metabolite changes, correlates, or predictors of antidepressant response. Metabolite levels were compared at three scan times (baseline, post-ketamine, and post-placebo) in HVs and MDD subjects at 7T using a 1H-MRS sequence specifically optimized for glutamate. No significant between-group differences in 1H-MRS-measured metabolites were observed at baseline. Antidepressant response was not predicted by baseline glutamate levels. Our results suggest that any infusion-induced increases in...Continue Reading

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Citations

Jul 25, 2018·Perspectives in Psychiatric Care·Brittany Carnley Steelman
Nov 7, 2019·Journal of Clinical Psychopharmacology·Nicholas A MischelSteven T Szabo
Jan 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christoph KrausJennifer W Evans
Sep 6, 2019·Psychopharmacology·Alice Egerton
Nov 25, 2019·Neuroimaging Clinics of North America·Anouk SchranteeLiesbeth Reneman
May 15, 2021·Frontiers in Psychiatry·Ajay SarawagiAnant Bahadur Patel
Jan 13, 2022·European Archives of Psychiatry and Clinical Neuroscience·Matti GärtnerSimone Grimm

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