8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid and its diastereomers improve age-related cognitive deterioration.

Lipids
T KannoTomoyuki Nishizaki

Abstract

Racemic 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a linoleic acid derivative with cyclopropane rings instead of cis-double bonds, contains possible four diastereomers such as α,α-, α,β-, β,α-, and β,β-DCP-LA. The present study examined the effect of racemic and diastereomeric DCP-LA on age-related learning and memory disorders using accelerated-senescence-prone mice 8 (SAMP8) and accelerated-senescence-resistant mice 1 (SAMR1). In the water maze test, the acquisition and retention latencies for SAMP8 mice were significantly longer than the latency for SAMR1 mice, indicating spatial learning and memory impairment for SAMP8 mice. All the racemic (1 mg/kg, per os) and diastereomeric DCP-LA (0.25 mg/kg, per os) significantly shortened the acquisition latency for SAMP8 mice, and racemic, α,α- and α,β-DCP-LA significantly shortened the retention latency, with the advantage greater than the acetylcholine (ACh) esterase inhibitor galanthamine. The results of the present study show that all the racemic and diastereomeric DCP-LA, has the potential to improve age-related learning and memory deterioration, the potential varying among them.

References

Sep 1, 1991·Journal of the American Geriatrics Society·T TakedaK Higuchi
Dec 20, 2005·Neuroreport·Takahiro YaguchiTomoyuki Nishizaki
Jun 6, 2009·Journal of Cellular Physiology·Takeshi KannoTomoyuki Nishizaki
Jan 5, 2011·Taiwanese Journal of Obstetrics & Gynecology·Tzong Yuan WuTzyy-Rong Jinn
Feb 18, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Tadashi ShimizuTomoyuki Nishizaki
Nov 1, 2011·British Journal of Clinical Pharmacology·Salvatore SalomoneFilippo Drago

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Citations

Jun 12, 2013·Lipids·Tomasz SledzinskiJulian Swierczynski
Apr 21, 2016·Behavioural Brain Research·Shuichi Yanai, Shogo Endo
Jan 24, 2015·Bioscience, Biotechnology, and Biochemistry·Kurara TakaganeShoichi Ishiura

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