89 Zr- and Fe-Labeled Polymeric Micelles for Dual Modality PET and T1 -Weighted MR Imaging

Advanced Healthcare Materials
Lucas W E StarmansHolger Grüll

Abstract

In this study, a new 89 Zr- and Fe3+ -labeled micelle nanoplatform (89 Zr/Fe-DFO-micelles) for dual modality position emission tomography/magnetic resonance (PET/MR) imaging is investigated. The nanoplatform consists of self-assembling amphiphilic diblock copolymers that are functionalized with 89 Zr-deferoxamine (89 Zr-DFO) and Fe3+ -deferoxamine (Fe-DFO) for PET and MR purposes, respectively. 89 Zr displays favorable PET imaging characteristics with a 3.3 d half-life suitable for imaging long circulating nanoparticles. The nanoparticles are modified with Fe-DFO as MR T1 -contrast label instead of commonly used Gd3+ -based chelates. As these micelles are cleared by liver and spleen, any long term Gd- related toxicity such as nephrogenic systemic fibrosis is avoided. As a proof of concept, an in vivo PET/MR study in mice is presented showing tumor targeting of 89 Zr/Fe-DFO-micelles through the enhanced permeability and retention (EPR) effect of tumors, yielding high tumor-to-blood (10.3 ± 3.6) and tumor-to-muscle (15.3 ± 8.1) ratios at 48 h post injection. In vivo PET images clearly delineate the tumor tissue and show good correspondence with ex vivo biodistribution results. In vivo magnetic resonance imaging (MRI) allows visua...Continue Reading

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Citations

Nov 11, 2017·Drug Delivery·Lingzhou ZhaoJinhua Zhao
Jan 8, 2020·Journal of Clinical Medicine·Ernesto ForteMarco Aiello
Oct 22, 2019·Molecular Pharmaceutics·Cátia DominguesAna Figueiras
Jul 30, 2020·Advanced Drug Delivery Reviews·Carlos Pérez-MedinaRoy van der Meel

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