8q24 allelic imbalance and MYC gene copy number in primary prostate cancer.

Prostate Cancer and Prostatic Diseases
H ChenRick A Kittles

Abstract

Four independent regions within 8q24 near the MYC gene are associated with risk for prostate cancer (Pca). Here, we investigated allelic imbalance (AI) at 8q24 risk variants and MYC gene DNA copy number (CN) in 27 primary Pcas. Heterozygotes were observed in 24 of 27 patients at one or more 8q24 markers and 27% of the loci exhibited AI in tumor DNA. The 8q24 risk alleles were preferentially favored in the tumors. Increased MYC gene CN was observed in 33% of tumors, and the co-existence of increased MYC gene CN with AI at risk loci was observed in 86% (P<0.004 exact binomial test) of the informative tumors. No AI was observed in tumors, which did not reveal increased MYC gene CN. Higher Gleason score was associated with tumors exhibiting AI (P=0.04) and also with increased MYC gene CN (P=0.02). Our results suggest that AI at 8q24 and increased MYC gene CN may both be related to high Gleason score in Pca. Our findings also suggest that these two somatic alterations may be due to the same preferential chromosomal duplication event during prostate tumorigenesis.

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Citations

Mar 13, 2012·Experimental Cell Research·Hankui ChenNalini Chandar
Apr 16, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bruce J TrockAngelo M De Marzo
Mar 3, 2015·Current Opinion in Urology·Ibrahim KulacAngelo M De Marzo
Feb 18, 2017·Genes·Richard J RebelloLuc Furic
Mar 21, 2021·Nature Communications·Musaddeque AhmedHousheng Hansen He

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Methods Mentioned

BETA
genotyping
PCR

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