9-Arylpurines as a novel class of enterovirus inhibitors

Journal of Medicinal Chemistry
Leire AguadoMaría-Jesús Pérez-Pérez

Abstract

Here we report on a novel class of enterovirus inhibitors that can be structurally described as 9-arylpurines. These compounds elicit activity against a variety of enteroviruses in the low microM range including Coxsackie virus A16, A21, A24, Coxsackie virus B3, and echovirus 9. Structure-activity relationship (SAR) studies indicate that a chlorine or bromine atom is required at position 6 of the purine ring for antiviral activity. The most selective compounds in this series inhibited Coxsackie virus B3 replication in a dose-dependent manner with EC(50) values around 5-8 microM. No toxicity on different cell lines was observed at concentrations up to 250 microM. Moreover, no cross-resistance to TBZE-029 and TTP-8307 CVB3 resistant strains was detected.

References

Jun 26, 1992·Journal of Medicinal Chemistry·D M HurynS Broder
Dec 19, 1996·Chemical Reviews·George A. Patani, Edmond J. LaVoie
May 29, 2002·Bioorganic & Medicinal Chemistry Letters·Mohamed BraktaShashikant Phadtare
Jul 26, 2002·Journal of Medicinal Chemistry·Eva-María PriegoMaría-Jesús Pérez-Pérez
May 6, 2003·Bioorganic & Medicinal Chemistry Letters·Yong-Jin WuHui-Yin Li
Sep 11, 2004·Viral Immunology·Sally Huber, Arlene I Ramsingh
Apr 2, 2005·Journal of Medicinal Chemistry·Anne Kristin BakkestuenBibigul T Utenova
Nov 10, 2005·The Journal of Organic Chemistry·Yoshihito UenoYukio Kitade
Apr 14, 2006·Current Pharmaceutical Design·Dale L Barnard
Sep 1, 2006·Journal of Medicinal Chemistry·Elena CasanovaMaría-Jesús Pérez-Pérez
Dec 30, 2006·Biochemical and Biophysical Research Communications·Armando M De PalmaJohan Neyts
Feb 8, 2007·Journal of Combinatorial Chemistry·He HuangHualiang Jiang
Mar 25, 2008·Current Topics in Microbiology and Immunology·K M Drescher, S M Tracy
Mar 25, 2008·Current Topics in Microbiology and Immunology·K U Knowlton
Apr 3, 2008·Medicinal Research Reviews·Armando M De PalmaJohan Neyts
Oct 22, 2008·The Journal of Antimicrobial Chemotherapy·Tzu-Chun ChenShin-Ru Shih
Jan 31, 2009·Journal of Combinatorial Chemistry·Leire AguadoMaría-Jesús Pérez-Pérez
Feb 25, 2009·Antimicrobial Agents and Chemotherapy·Armando M De PalmaJohan Neyts
Mar 21, 2009·Bioorganic & Medicinal Chemistry Letters·Jimmy J WeteringsDmitri V Filippov
Jun 18, 2009·Organic & Biomolecular Chemistry·Yoshihito UenoYukio Kitade

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Citations

Oct 19, 2013·Journal of Medicinal Chemistry·Stéphane PautusStephen Cusack
Apr 12, 2014·PLoS Pathogens·Hendrik Jan ThibautJohan Neyts
Feb 3, 2011·Beilstein Journal of Organic Chemistry·Carolin Fischer, Burkhard Koenig
May 4, 2012·Medicinal Research Reviews·Erik De Clercq
Sep 1, 2015·The Journal of Organic Chemistry·Sk RasheedParthasarathi Das
Oct 6, 2014·European Journal of Medicinal Chemistry·María-Dolores CanelaMaría-Jesús Pérez-Pérez
Mar 1, 2014·Chemical Communications : Chem Comm·Anders Foller Larsen, Trond Ulven
Jun 11, 2011·Organic & Biomolecular Chemistry·Hong-Ying NiuHai-Ming Guo

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