9-cis retinoic acid modulates the type I allergic immune response

The Journal of Allergy and Clinical Immunology
G HeineM Worm

Abstract

Vitamin A is a potent regulator of adaptive immunity. The effect of the endogenous metabolite 9-cis retinoic acid (9cRA) on allergic sensitization is unknown. We sought to investigate whether and to what extent 9cRA modulates the humoral immune response. BALB/c mice were sensitized and challenged with ovalbumin (OVA). 9cRA was applied repeatedly together with the antigen. Immunoglobulin production and cellular analysis were performed by using ELISA, ELISpot, and flow cytometry. Human CD19(+) B cells were activated in vitro in the presence or absence of 9cRA and activation markers, and proliferation and secreted immunoglobulin levels were analyzed by using flow cytometry and ELISA. 9cRA applied together with repeated OVA challenge transiently increased specific serum IgA, IgE, and IgG1 serum levels (2.0- and 8.9-fold). After OVA recall, specific IgE concentrations were reduced by a mean of 57% after adding 9cRA, whereas IgA was strongly induced (20-fold), and IgG1 levels remained unchanged. Correspondingly, less specific IgE- and more IgA-secreting cells resided in the spleen in the 9cRA groups. Additionally, 9cRA promoted the migration of specific B cells to the mesenteric but not draining lymph nodes. In purified stimulated hu...Continue Reading

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M Smith, C E Hayes
Apr 18, 2001·International Archives of Allergy and Immunology·M WormB M Henz
Nov 25, 2003·The Journal of Investigative Dermatology·Ralph RühlMargitta Worm
May 11, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·F ScheffelM Worm
Nov 18, 2006·Science·J Rodrigo MoraUlrich H von Andrian
May 17, 2008·Nature Reviews. Immunology·Andrea Cerutti
Jul 25, 2008·European Journal of Immunology·Guido HeineMargitta Worm
Jan 28, 2009·Nature Reviews. Immunology·J Rodrigo MoraUlrich H von Andrian
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guido HeineMargitta Worm
Apr 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M MilovanovicM Worm
Oct 10, 2009·The Journal of Allergy and Clinical Immunology·Elke O LugerHarald Renz
Apr 2, 2010·International Journal of Epidemiology·Christopher R SudfeldNeal A Halsey
Oct 12, 2010·The Journal of Allergy and Clinical Immunology·Milena MilovanovicMargitta Worm
Mar 23, 2011·Biochemical and Biophysical Research Communications·Kerstin Geldmeyer-HiltMargitta Worm
Jul 9, 2011·The Journal of Clinical Investigation·Swantje I HammerschmidtReinhold Förster
Jul 12, 2011·Experimental Dermatology·Christin WeiseMargitta Worm
Jul 23, 2011·Immunity·Jason A HallYasmine Belkaid
Sep 12, 2013·International Archives of Allergy and Immunology·Gerco den HartogR J Joost van Neerven
Mar 20, 2014·European Journal of Immunology·Guido HeineMargitta Worm
Jun 22, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guido HeineMargitta Worm
Oct 4, 2014·International Archives of Allergy and Immunology·Mandana SchindlerMargitta Worm

❮ Previous
Next ❯

Citations

Jun 20, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Huan YangHua Wang
Sep 12, 2018·Journal of Clinical Medicine·Zhiyi HuangSong Guo Zheng
May 1, 2018·Allergo Journal International·Karin Hufnagl, Erika Jensen-Jarolim
Feb 28, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Maya W HaakerJ Bernd Helms

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Related Papers

Cellular Immunology
Luana Pereira Antunes DouradoDenise Carmona Cara
The Journal of Immunology : Official Journal of the American Association of Immunologists
G HeineM Worm
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
M C TunisJ S Marshall
© 2022 Meta ULC. All rights reserved