PMID: 11905979Mar 22, 2002Paper

9 clinical cases of nonhealing pressure ulcers in patients with spinal cord injury treated with an anabolic agent: a therapeutic trial

Advances in Skin & Wound Care
Ann M SpungenWilliam A Bauman

Abstract

Anabolic steroid agents may potentially promote wound healing in individuals with spinal cord injury who have long-standing wounds. Nine patients hospitalized on the Spinal Cord Injury Service of the VA Medical Center, Bronx, NY, received treatment with an anabolic agent and amino acid supplement. Selection of patients was based on having at least 1 of the following criteria: (1) nonhealing pressure ulcer of at least 2 months' duration with no change or worsening status, and/or (2) full-thickness pressure ulcer through fascia into muscle, tendon, or bone. Previous and current pressure ulcer histories were determined by review of the hospital records when available and/or self-reporting by the patient. Eight of 9 patients had nonhealing wounds of 2 months' to 5 years' duration. One patient was included because of having a large, full-thickness pressure ulcer of reportedly 2 weeks' duration. Except for 1 Stage III pressure ulcer, all others had Stage IV pressure ulcers.Three patients had documented weight loss (>10% of total body weight), 3 had no recent weight loss, and 3 refused to be weighed. Patients were treated from 1 to 12 months with oxandrolone (20 mg/day) and glutamine (20 g/day). Eight of 9 patients completely healed: ...Continue Reading

References

Sep 1, 1973·Clinical Pharmacology and Therapeutics·A KarimH I Maibach
Feb 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J BarbosaR P Doe
Apr 1, 1983·Metabolism: Clinical and Experimental·S M HaffnerW R Hazzard
Aug 1, 1995·American Journal of Hematology·G S FerenchickK A Schwartz
Aug 1, 1994·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R G Barton
Apr 29, 1998·The Journal of Burn Care & Rehabilitation·R H Demling, L DeSanti
May 28, 1998·Spinal Cord·J S Krause
Dec 9, 1995·International Journal of Health Care Quality Assurance·E M EinspruchN G Einspruch
Nov 24, 1999·Archives of Physical Medicine and Rehabilitation·W O McKinleyM J DeVivo
Sep 1, 1962·The Journal of Clinical Endocrinology and Metabolism·M FOXG W LIDDLE

❮ Previous
Next ❯

Citations

Nov 5, 2003·AACN Clinical Issues·Mary C Arnold
Mar 21, 2002·Advances in Skin & Wound Care·R Salcido, K E Barner
Dec 13, 2002·Advances in Skin & Wound Care·Robert J Goldman
Sep 15, 2005·Advances in Skin & Wound Care·Richard Salcido
Aug 21, 2004·Annals of Surgery·Eileen M BulgerRonald V Maier
Mar 22, 2006·Expert Opinion on Investigational Drugs·Scott SegalJames T Dalton
Jul 10, 2007·Journal of the American Medical Directors Association·Shing-Shing YehMichael W Schuster
Feb 25, 2009·Archives of Physical Medicine and Rehabilitation·Mary Ann ReganUNKNOWN Spinal Cord Injury Rehabilitation Evidence Research Team
Jan 15, 2014·Hospital Pharmacy·Joyce A Generali, Dennis J Cada
Nov 29, 2011·Journal of the American Dietetic Association·Emanuele CeredaRiccardo Caccialanza
Jun 21, 2017·The Cochrane Database of Systematic Reviews·Cho Naing, Maxine A Whittaker
Apr 26, 2002·Archives of Physical Medicine and Rehabilitation·William O McKinleySuzanne L Groah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.