Δ9-Tetrahydrocannabinol suppresses monocyte-mediated astrocyte production of MCP-1 and IL-6 in a TLR7-stimulated human co-culture

The Journal of Pharmacology and Experimental Therapeutics
Michael D RizzoNorbert E Kaminski

Abstract

Cannabis is widely used in the United States with an estimated prevalence of 9.5%. Certain cannabinoids in Cannabis sativa, in particular, Δ9-tetrahydrocannabinol (THC), possess immune modulating and anti-inflammatory activity. Depending on the context, the anti-inflammatory activity of cannabinoids may be beneficial, such as in treating inflammatory diseases, or detrimental to normal immune defense against pathogens. The potential beneficial impact of cannabinoids on chronic neuroinflammation has gained recent attention. Monocyte migration to the brain has been implicated as a key event in chronic neuroinflammation and in the etiology of central nervous system diseases including viral infection (e.g., HIV-associated neurocognitive disorder). In the brain, monocytes can contribute to neuroinflammation through interactions with astrocytes, including inducing astrocyte secretion of cytokines and chemokines. In a human co-culture system, monocyte-derived IL-1β due to toll-like receptor 7 (TLR7)-activation, has been identified to promote astrocyte production of MCP-1 and IL-6. THC treatment of TLR7-stimulated co-culture suppressed monocyte secretion of IL-1β resulting in decreased astrocyte production of MCP-1 and IL-6. Furthermore...Continue Reading

References

Jan 1, 1997·Pharmacology & Therapeutics·R G Pertwee
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Robert J McKallipPrakash S Nagarkatti
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Jul 19, 2005·Journal of Neuroimmunology·J Ludovic Croxford, Takashi Yamamura
Jan 18, 2006·Cell Death and Differentiation·T Kawai, S Akira
Dec 23, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Catherine LombardPrakash Nagarkatti
Aug 23, 2007·Chemistry & Biodiversity·Marilyn A Huestis
Aug 30, 2007·The Journal of Pharmacology and Experimental Therapeutics·John P BuchweitzNorbert E Kaminski
Oct 2, 2007·British Journal of Pharmacology·A J Brown
Jan 21, 2009·Expert Reviews in Molecular Medicine·Guy A Cabral, LaToya Griffin-Thomas
May 22, 2009·Immunobiology·Sadiye Amcaoglu RiederPrakash Nagarkatti
Dec 17, 2009·Acta Neuropathologica·Michael V Sofroniew, Harry V Vinters
Feb 16, 2010·Immunobiology·Radu Tanasescu, Cris S Constantinescu
Mar 9, 2010·Biochemical Pharmacology·Barbara BosierDidier M Lambert
Jul 27, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Peer W F KarmausNorbert E Kaminski
Oct 25, 2011·Cytokine & Growth Factor Reviews·Gloria Lopez-Castejon, David Brough
Mar 21, 2012·Immunologic Research·Kok Loon WongSiew Cheng Wong
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heidi A JurgensRodney W Johnson
May 10, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anupa KamatDana Gabuzda
Jun 23, 2012·Frontiers in Microbiology·Samantha R Furr, Ian Marriott
Nov 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Peer W F KarmausNorbert E Kaminski
Dec 5, 2012·PLoS Pathogens·Hilario J RamosMichael Gale
Dec 19, 2012·Journal of Neuroinflammation·Rachael L TerryNicholas J C King
Mar 9, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Slava Rom, Yuri Persidsky
Aug 29, 2013·Therapeutic Advances in Psychopharmacology·Zerrin Atakan
Feb 25, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Julie C WilliamsMaureen M Goodenow
Jun 13, 2014·Journal of Neuroinflammation·Deidre JanssonMike Dragunow
Aug 12, 2014·Molecular Pharmacology·Amey Dhopeshwarkar, Ken Mackie
Sep 2, 2014·International Review of Neurobiology·Guy A Cabral, Melissa Jamerson
Jan 24, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Michael D RothSylvia M Kiertscher
Jan 27, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Albert M AndersonUNKNOWN HIV Neuroimaging Consortium

❮ Previous
Next ❯

Citations

May 16, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Michael D RizzoNorbert E Kaminski
Sep 16, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rowan SalonerUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
Feb 16, 2021·Frontiers in Immunology·Santosh V SuryavanshiOlga Kovalchuk
Jul 16, 2021·Journal of the International Neuropsychological Society : JINS·C Wei-Ming WatsonIgor Grant
Aug 29, 2021·Viruses·Ronald J EllisScott Peterson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.