90 Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin's Lymphoma

Communications Biology
Reinier HernandezJamey Weichert

Abstract

Finding improved therapeutic strategies against T-cell Non-Hodgkin's Lymphoma (NHL) remains an unmet clinical need. We implemented a theranostic approach employing a tumor-targeting alkylphosphocholine (NM600) radiolabeled with 86Y for positron emission tomography (PET) imaging and 90Y for targeted radionuclide therapy (TRT) of T-cell NHL. PET imaging and biodistribution performed in mouse models of T-cell NHL showed in vivo selective tumor uptake and retention of 86Y-NM600. An initial toxicity assessment examining complete blood counts, blood chemistry, and histopathology of major organs established 90Y-NM600 safety. Mice bearing T-cell NHL tumors treated with 90Y-NM600 experienced tumor growth inhibition, extended survival, and a high degree of cure with immune memory toward tumor reestablishment. 90Y-NM600 treatment was also effective against disseminated tumors, improving survival and cure rates. Finally, we observed a key role for the adaptive immune system in potentiating a durable anti-tumor response to TRT, especially in the presence of microscopic disease.

References

Oct 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S KaminskiJ M Vose
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigChristine A White
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigPratik S Multani
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mala ChakrabortyJames W Hodge
Jul 1, 1961·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E N RAMSDEN
Jul 6, 2004·Current Treatment Options in Oncology·Andrew M Evens, Ronald B Gartenhaus
Dec 23, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra J HorningMichael Goris
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John F DiJosephNitin K Damle
Aug 24, 2005·Cancer Biotherapy & Radiopharmaceuticals·William H MillerWynn A Volkert
Sep 28, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard I FisherMorton Coleman
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amit A LugadeEdith M Lord
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie VoseUNKNOWN International T-Cell Lymphoma Project
Jan 2, 2010·Science·Daniel Lingwood, Kai Simons
Apr 13, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Mark Lubberink, Hans Herzog
Nov 9, 2011·The British Journal of Dermatology·D V ChanK D Cooper
Dec 14, 2011·Hematology·Kerry J Savage
Jun 5, 2013·Therapeutic Advances in Hematology·Andrei Shustov
Jan 3, 2014·The Journal of Clinical Investigation·Liufu DengYang-Xin Fu
Jun 13, 2014·Science Translational Medicine·Jamey P WeichertJohn S Kuo
Sep 10, 2014·Cancer Treatment Reviews·Bertrand CoiffierPier Luigi Zinzani
Nov 12, 2014·Physics in Medicine and Biology·L JødalC Champion
Oct 5, 2015·Dermatologic Clinics·Daniel J TandbergChris R Kelsey
Aug 24, 2016·Current Opinion in Urology·Shaveta MehtaAnanya Choudhury
Sep 24, 2016·Journal for Immunotherapy of Cancer·Josephine KangSilvia Formenti
Oct 5, 2016·JCI Insight·Grit S Herter-SprieKwok-Kin Wong
Nov 1, 2016·Nature Reviews. Immunology·Lorenzo GalluzziGuido Kroemer
May 26, 2017·The British Journal of Radiology·Evert J Van LimbergenPhilippe Lambin
Feb 28, 2018·Critical Reviews in Oncology/hematology·Loredana MarcuBarry J Allen
May 12, 2018·Cancer Immunology Research·Zachary S MorrisPaul M Sondel
Jun 29, 2018·Journal of Thoracic Disease·Neeraj BhallaMichael Brada

❮ Previous
Next ❯

Citations

May 25, 2020·Cancer Immunology, Immunotherapy : CII·Jacques RouanetPaul-Olivier Rouzaire
Oct 21, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Patrycja GuzikCristina Müller
Jul 11, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Johannes CzerninKatharina Lückerath
Dec 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Reinier HernandezJamey P Weichert
Jun 7, 2021·Seminars in Radiation Oncology·Zachary MorrisRobert Timmerman
Jul 16, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter M CarlsonPaul M Sondel
Nov 1, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eduardo Aluicio-SarduyJonathan W Engle
Aug 20, 2021·NMR in Biomedicine·Lawrence M LechugaSean B Fain
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
irradiating
ELISA

Software Mentioned

Optiquant

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Joseph J GrudzinskiJamey Weichert
Current Treatment Options in Oncology
Andrew M Evens, Ronald B Gartenhaus
Mymensingh Medical Journal : MMJ
A AkhterN Haque
Zhonghua wai ke za zhi [Chinese journal of surgery]
Jiao-lin ZhouJian Li
© 2022 Meta ULC. All rights reserved