96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures

AIDS
Margaret A JohnsonColin McLaren

Abstract

In BMS Study 045, once-daily (QD) atazanavir/ritonavir (ATV/RTV) demonstrated comparable efficacy and safety to twice-daily (BID) lopinavir/ritonavir (LPV/RTV) over 48 weeks in treatment-experienced patients. Results of extended follow-up to 96 weeks are presented. BMS Study 045 was an open-label, randomized, multi-national trial of HIV-infected patients with virologic failure on two or more prior HAART regimens designed to evaluate the efficacy and safety of ATV/RTV (300/100 mg) QD and LPV/RTV (400/100 mg) BID, each with tenofovir (300 mg) QD and one nucleoside reverse transcriptase inhibitor. The primary efficacy measure was the time-averaged difference (TAD) in reduction in HIV RNA from baseline. Secondary objectives included evaluation of safety and plasma lipid levels through week 96. Over 96 weeks, the ATV/RTV regimen demonstrated similar virologic efficacy to the LPV/RTV regimen. Mean reductions from baseline in HIV RNA were -2.29 and -2.08 log10 copies/ml, respectively [TAD (97.5% confidence interval): 0.14 log10 copies/ml (-0.13, 0.41)]. The LPV/RTV regimen resulted in significant increases in total cholesterol (+9%) and fasting triglycerides (+30%) in comparison with the ATV/RTV regimen, which demonstrated decreases i...Continue Reading

References

Oct 3, 1999·Annals of Internal Medicine·T E Flynn, L A Bricker
Oct 3, 1999·Annals of Internal Medicine·D DuclouxJ M Chalopin
May 3, 2000·Lancet·J Mellors, J Montaner
Dec 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C HadiganS Grinspoon
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H RexJ E Edwards
Dec 14, 2002·Lancet·Scott D HolmbergUNKNOWN HIV Outpatient Study (HOPS) investigators
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Félix GutiérrezAlberto Martin-Hidalgo
Aug 19, 2003·The Annals of Pharmacotherapy·Patricia Pecora Fulco, Margaret A Kirian
Nov 6, 2003·AIDS·Murielle Mary-KrauseUNKNOWN Clinical Epidemiology Group from the French Hospital Database
May 25, 2004·Antimicrobial Agents and Chemotherapy·Anne-Marie TaburetPierre-Marie Girard
Jul 14, 2004·JAMA : the Journal of the American Medical Association·Patrick G YeniPaul A Volberding
Aug 11, 2005·Current HIV/AIDS Reports·Joel E Gallant

❮ Previous
Next ❯

Citations

Feb 3, 2011·Journal of General Internal Medicine·Michael D AprilRochelle P Walensky
Dec 3, 2003·Current Infectious Disease Reports·Michael Neely, Andrea Kovacs
Oct 27, 2006·Current Infectious Disease Reports·Todd T Brown, Joseph Cofrancesco
Dec 1, 2008·Enfermedades infecciosas y microbiología clínica·Laura Zamora, José María Gatell
Sep 25, 2009·Nature Reviews. Nephrology·Hassane IzzedineMark A Perazella
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan A Winston, David H Shepp
Oct 25, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan WinstonBenjamin Young
Jan 2, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melissa A BenderKenneth A Freedberg
May 30, 2008·AIDS Research and Human Retroviruses·Sonia Rodríguez-NóvoaVincent Soriano
Jun 16, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodger D MacArthur, Herbert L DuPont
Aug 18, 2010·The Journal of Antimicrobial Chemotherapy·Adrian CurranEsteban Ribera
Jun 12, 2010·AIDS·François-Xavier LescureGilles Pialoux
Jan 23, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine TassiopoulosUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials 219C Team
Jun 30, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Benjamin P LinasKenneth A Freedberg
Jun 30, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gilles WandelerUNKNOWN IeDEA Southern Africa Collaboration
Mar 30, 2010·HIV Medicine·R RubioUNKNOWN GESIDA 44/04 SIMPATAZ Study Group
May 17, 2007·International Journal of Clinical Practice·L Waters, M Nelson
Jun 20, 2007·Antimicrobial Agents and Chemotherapy·Edward P AcostaDavid W Haas
Nov 21, 2007·Antimicrobial Agents and Chemotherapy·Jennifer J KiserUNKNOWN Adolescent Trials Network for HIV/AIDS Interventions
Jan 12, 2010·Journal of Medical Case Reports·Alessia UgliettiRenato Maserati
Sep 17, 2010·PloS One·Chara E RydzakUNKNOWN CEPAC Investigators
Dec 25, 2013·PloS One·Yazdan YazdanpanahA David Paltiel
May 14, 2009·Therapeutics and Clinical Risk Management·Pablo RivasVincent Soriano
Jun 6, 2009·Drugs·Katherine F CroomSusan J Keam
Mar 4, 2009·PharmacoEconomics·Kit N SimpsonRukmini Rajagopalan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.