96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B

Journal of Hepatology
Chee-Kin HuiGeorge K K Lau

Abstract

In order to prevent the occurrence of drug-resistant mutants associated with treatment for chronic hepatitis B virus (HBV) infection, combination therapy is being developed. To determine the efficacy of adefovir dipivoxil (ADV) plus emtricitabine (FTC) combination therapy in chronic HBV infection. Thirty treatment-nai ve, HBeAg-positive patients were randomized to combination ADV plus FTC (n=14) or ADV plus placebo monotherapy (n=16) for 96 weeks. HBV DNA was measured by polymerase chain reaction. Treatment was stopped in those with HBeAg seroconversion. The median decrease in HBV DNA at week 96 was higher in the combination group (-5.30 vs. -3.98 log(10)copies/ml, p=0.05). More patients in the combination group had normalization of alanine aminotransaminase and HBV DNA<300 copies/ml at week 96 when compared with the monotherapy group [11 of the 14 patients (78.6%) vs. 6 of the 16 patients (37.5%), p=0.03]. However, HBeAg seroconversion at week 96 was similar in the 2 groups [2/14 (14.3%) vs. 4/16 (25.0%), p=NS]. No ADV or FTC resistance was detected at week 96. In those with HBeAg seroconversion, 50.0% had post-treatment relapse. Combination ADV plus FTC resulted in more potent suppression of HBV DNA over 96 weeks of therapy.

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jan 1, 1995·Annual Review of Immunology·F V Chisari, C Ferrari
Jul 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D ColledgeT Shaw
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·D ColledgeT Shaw
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C Seeger, W S Mason
Mar 18, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·N Clumeck, S De Wit
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G K LauS Lam
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B C SongY S Lee
Nov 22, 2002·The New England Journal of Medicine·Andreas GeierChristoph G Dietrich
Feb 28, 2003·The New England Journal of Medicine·Stephanos J HadziyannisUNKNOWN Adefovir Dipivoxil 438 Study Group
Feb 28, 2003·The New England Journal of Medicine·Patrick MarcellinUNKNOWN Adefovir Dipivoxil 437 Study Group
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jules L DienstagEugene Schiff
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rong-Nan ChienYun-Fan Liaw
Sep 17, 2004·The New England Journal of Medicine·Patrick MarcellinUNKNOWN Peginterferon Alfa-2a HBeAg-Negative Chronic Hepatitis B Study Group
Feb 17, 2005·Journal of the National Cancer Institute·Ming-Whei YuChien-Jen Chen
Jul 1, 2005·The New England Journal of Medicine·George K K LauUNKNOWN Peginterferon Alfa-2a HBeAg-Positive Chronic Hepatitis B Study Group
Jul 1, 2005·The New England Journal of Medicine·Anna Suk-Fong Lok
Jan 13, 2006·Archives of Internal Medicine·Seng Gee LimUNKNOWN Emtricitabine FTCB-301 Study Group
Jul 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeTeresa L Wright
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon

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Citations

Feb 3, 2009·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Shaili Gupta, Frederick L Altice
Jan 27, 2009·Current Gastroenterology Reports·John D Scott, Brian McMahon
Aug 25, 2009·Current Infectious Disease Reports·Melissa Osborn
Oct 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Debika Bhattacharya, Chloe L Thio
Jun 10, 2011·Current Hepatitis Reports·Navin Paul, Steven-Huy Han
Jan 17, 2012·Expert Opinion on Pharmacotherapy·Maria C SegoviaStuart C Gordon
Oct 27, 2009·Expert Opinion on Investigational Drugs·Ivana Carey, Phillip M Harrison
Jun 16, 2011·Expert Opinion on Drug Safety·Mauro ViganòMassimo Colombo
Apr 7, 2009·Gastroentérologie Clinique Et Biologique·J-P Zarski
Mar 28, 2009·The Lancet Infectious Diseases·Man-Fung YuenChing-Lung Lai
Oct 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeHillel Tobias
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A Terrault
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Fabien ZoulimPaul Deny
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sharon R LewinGregory J Dore
Jan 5, 2011·Alimentary Pharmacology & Therapeutics·V RijckborstH L A Janssen
Feb 18, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Patrick MarcellinTeerha Piratvisuth
Feb 29, 2008·Journal of Hepatology·Fabien Zoulim, Robert Perrillo
Dec 9, 2010·International Journal of STD & AIDS·G BrookC Bergin
Jan 21, 2010·The American Journal of Gastroenterology·Alexander MontoIra M Jacobson
Oct 27, 2009·Drugs·Grace L-H Wong, Henry L-Y Chan
Apr 9, 2010·The Korean Journal of Hepatology·Jung Min Lee, Sang Hoon Ahn
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J Fontana
Apr 1, 2008·Alimentary Pharmacology & Therapeutics·M Kumar, S K Sarin
Oct 31, 2009·World Journal of Hepatology·Konstantinos Tziomalos
Aug 16, 2012·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Aug 13, 2013·Hepatology International·Hamad I Al-AshgarKhalid I Bzeizi

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