99m Tc-MIBI Scintigraphy for the Preoperative Assessment of Histological Response to Neoadjuvant Chemotherapy in Patients With Osteosarcoma: A Systematic Review and a Bivariate Meta-Analysis

Frontiers in Oncology
Fashuai WuZengwu Shao

Abstract

Purpose: There have been many attempts to preoperatively evaluate the chemotherapy response of osteosarcoma patients using 99mTc-MIBI scintigraphy. However, the evaluations were lacking in consistency. We performed this systematic review and meta-analysis to systematically evaluate the ability of 99mTc-MIBI scintigraphy in preoperatively assessing the response of osteosarcoma patients to neoadjuvant chemotherapy. Methods: For this systematic review and meta-analysis, PubMed, Web of Science, OVID, the Cochrane Library, and CNKI were searched. Eligible studies were included based on the defined criteria. The index test was 99mTc-MIBI scintigraphy, the reference standard was tumor necrosis rate. Quality Assessment of Diagnostic Accuracy Studies-2 was adopted for quality assessment of included studies. The statistical pooling analysis, meta-regression analysis, subgroup analysis, sensitivity analysis, and publication bias of our research were performed using STATA 15. Results: Eight articles with 189 osteosarcoma patients were included in this systematic review and meta-analysis. Our results demonstrated that the threshold effect of our meta-analysis was significant. The uptake change ratio of 99mTc-MIBI scintigraphy had a pooled s...Continue Reading

References

Jun 3, 1988·Science·J A Swets
Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·M Salzer-KuntschikR Sigmund
May 1, 1997·European Journal of Nuclear Medicine·V SöderlundH Jacobsson
Jan 12, 2002·Clinical Nuclear Medicine·Leonard P ConnollyS Ted Treves
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan S BielackKurt Winkler
Aug 24, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaetano BacciPiero Picci
Sep 20, 2005·Journal of Clinical Epidemiology·Johannes B ReitsmaAeilko H Zwinderman
Feb 24, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J A M BramerR J P M Scholten
Apr 5, 2011·Clinical & Experimental Metastasis·J PosthumaDeBoerB J van Royen
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Jul 30, 2014·Cancer Treatment and Research·Drew D Moore, Hue H Luu
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S IsakoffRichard Gorlick
Dec 10, 2016·Rheumatology and Therapy·Brock A LindseyEugenie S Kleinerman
Jan 25, 2018·JAMA : the Journal of the American Medical Association·Matthew D F McInnesBrian H Willis
May 7, 2019·Pediatric Blood & Cancer·Emanuela PalmeriniStefano Ferrari

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