(99m) Tc radiolabeling and biological evaluation of nanoparticles functionalized with a versatile coating ligand

Chemistry : a European Journal
Michael FelberRoger Alberto

Abstract

Radiolabeling allows noninvasive imaging by single photon emission computed tomography (SPECT) or positron emission tomography (PET) for assessing the biodistribution of nanostructures. Herein, the synthesis of a new coating ligand for gold nanoparticles (AuNPs) and quantum dots (QDs) is reported. This ligand is multifunctional; it combines the metal chelate with conjugating functions to biological vectors. The concept allows the coupling of any targeting function to the chelator; an example for the prostate specific membrane antigen is given. Derivatized NPs can directly be labeled in one step with [(99m) Tc(OH2 )3 (CO)3 ](+) . AuNPs in particular are highly stable, a prerequisite for in vivo studies excluding misinterpretation of the biodistribution data. AuNPs with differing sizes (7 and 14 nm core diameter) were administered intravenously into nude NMRI mice bearing LNCaP xenografts. MicroSPECT images show for both probes rapid clearance from the blood pool through the hepatobiliary pathway. The 7 nm AuNPs revealed a significantly higher bone uptake than the 14 nm AuNPs. The high affinity towards bone mineral is further confirmed in vitro with hydroxyapatite.

References

Oct 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Norbert SchülkeWilliam C Olson
Dec 29, 2006·Small·Joseph M SlocikRajesh R Naik
Apr 5, 2007·Nature Protocols·Aaron R ClappHedi Mattoussi
Jun 15, 2007·Journal of Medicinal Chemistry·Cyril BarinkaJacek Lubkowski
Aug 21, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Meike L SchipperSanjiv S Gambhir
Sep 25, 2007·Nature Biotechnology·Hak Soo ChoiJohn V Frangioni
Oct 19, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Weibo CaiXiaoyuan Chen
Feb 27, 2008·Angewandte Chemie·Sabrina BuchiniStephen G Withers
Aug 5, 2008·Molecular Pharmaceutics·Frank AlexisOmid C Farokhzad
May 9, 2009·Nano Letters·Hak Soo ChoiJohn V Frangioni
Aug 7, 2009·Chemistry : a European Journal·Do Won HwangSoonhag Kim
Jan 12, 2011·Nuclear Medicine and Biology·Blanca E Ocampo-GarcíaMarco A Camacho-López
Feb 23, 2011·Bioconjugate Chemistry·Rafael Torres Martin de RosalesPhilip J Blower
Mar 18, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Joshua ZylstraMathew M Maye
Apr 26, 2011·Nature Nanotechnology·Eun Chul ChoYounan Xia
May 7, 2011·Accounts of Chemical Research·Twan LammersFabian Kiessling
Jun 9, 2011·Accounts of Chemical Research·Nandanan Erathodiyil, Jackie Y Ying
Jul 2, 2011·Nanomedicine·Jesse V JokerstSanjiv S Gambhir
Aug 24, 2011·Nuclear Medicine Communications·Blanca Ocampo-GarcíaFlor de María Ramírez
Sep 17, 2011·Accounts of Chemical Research·Jesse V Jokerst, Sanjiv S Gambhir
Oct 7, 2011·Molecular Pharmaceutics·Ruth Duncan, Rogerio Gaspar
Dec 16, 2011·Chemical Society Reviews·Shahriar SharifiMorteza Mahmoudi
Sep 4, 2012·Journal of the American Chemical Society·Goutam PaluiHedi Mattoussi
Oct 31, 2012·ACS Applied Materials & Interfaces·Juliana TournebizeRaphaël Schneider
Dec 21, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Maroor Raghavan Ambikalmajan PillaiF F Russ Knapp
Jan 9, 2013·Accounts of Chemical Research·Sung Tae KimVincent M Rotello
Jun 5, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shawn M HillierJohn W Babich
Aug 24, 2013·Accounts of Chemical Research·Bing WangWeiyue Feng

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Citations

Mar 26, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Kristof ZarschlerKenneth A Dawson
Apr 21, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·S ImstepfR Alberto
Aug 20, 2020·Chemical Communications : Chem Comm·Steven Y YapGraeme J Stasiuk
Sep 25, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Angelo FreiRoger Alberto
Jan 26, 2021·Chemical Society Reviews·Juan PellicoRafael T M de Rosales

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