99m Tc]Tc-duramycin, a potential molecular probe for early prediction of tumor response after chemotherapy

Nuclear Medicine and Biology
Yi LiYingjian Zhang

Abstract

Apoptosis plays a crucial role in many biological processes, especially in cancer. However, real-time monitoring of apoptosis is challenging. [99mTc]duramycin can selectively target an apoptosis biomarker: phosphatidylethanolamine (PE), which is normally located on the intracellular cell-membrane surface but redistributes onto the outer cell-membrane upon apoptosis. Therefore, 99mTc-duramycin is a potential probe for non-invasive detection of apoptosis in real-time. The aim of this study was to evaluate the value of [99mTc]duramycin for detecting early apoptotic response in tumors after chemotherapy, thus providing a tool for early prediction of curative effects in tumors. Human breast cancer MDA-MB-468 model mice, randomly divided into two groups, were injected with cisplatin or vehicle once per day. [99mTc]duramycin imaging was performed for group 1 before treatment and 24 h after the third day of treatment to evaluate treatment response through animal single-photon emission computed tomography (SPECT/CT). Mice in group 2 were treated for 10 days consecutively, to observe treatment response by tumor volume changes. Treatment response was further demonstrated through TdT-mediated dUTP nick-end labeling (TUNEL) and cleaved casp...Continue Reading

Citations

Dec 13, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gongjun YuanGanghua Tang
Mar 10, 2020·Bioconjugate Chemistry·Dongjian ZhangJian Zhang
Jun 14, 2020·Current Medicinal Chemistry·Mona MosayebniaSoraya Shahhosseini
Dec 8, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Xiyi QinMei Tian

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