⁹⁹mTc-anti-TNF-α antibody for the imaging of disease activity in pulmonary sarcoidosis

The European Respiratory Journal
Roeland VisRuth G M Keijsers

Abstract

Infliximab, a monoclonal antibody directed against tumour necrosis factor (TNF)-α, is used in the treatment of refractory sarcoidosis. However, the clinical response is variable and a tool to select responders beforehand is highly desirable. In this study we evaluated scintigraphy with technetium-99m ((99m)Tc)-labelled infliximab for the imaging of disease activity in patients with pulmonary sarcoidosis.10 patients were studied using single photon emission computed tomography/computed tomography (CT) 6 h and 20 h after intravenous administration of 370 MBq of(99m)Tc-infliximab. Correlation analysis was performed between tissue accumulation of(99m)Tc-infliximab and laboratory parameters (including soluble interleukin-2 receptor and angiotensin-converting enzyme), lung function parameters (including forced expiratory volume in 1 s and the diffusing capacity of the lung for carbon monoxide) and(18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT.Analysis showed selective and variable accumulation of(99m)Tc-infliximab in the target tissue. Accumulation correlated positively with all four laboratory parameters and negatively with all four lung function parameters, yielding better correlations than serum TNF-α levels ...Continue Reading

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Citations

Feb 10, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rayan SaabFadi G Hage
Jun 26, 2020·Frontiers in Immunology·Claire E McCarthyHeather M Gibson
Aug 8, 2020·Frontiers in Immunology·Raisa KraaijvangerMarcel Veltkamp
Jan 28, 2017·World Journal of Gastroenterology : WJG·Rachel Marion-LetellierCéline Savoye-Collet

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