99mTc-DTPA and 131I-hippuran findings in liver transplant recipients treated with cyclosporin A

G KlintmalmT E Starzl


The effects of cyclosporin A (CyA), an immunosuppressive agent that is potentially nephrotoxic, on the kidneys of 9 liver transplant recipients were studied with serial 99mTc-DTPA and 131I-hippuran scans. In addition, renal function was determined by measuring serum creatinine levels during the second postoperative week in the 9 unselected CyA-treated patients and, retrospectively, in a control group of 29 liver transplant recipients who had not been treated with CyA and who were selected because they had survived for at least 3 months postoperatively. The early postoperative creatinine level was significantly greater in the CyA group. Eight of the 9 CyA patients showed imaging abnormalities in all preoperative and postoperative studies. Five of the 8 patients showed a pattern similar to that of acute tubular necrosis (relatively preserved perfusion) in at least one study. Lowering the dosage of CyA permitted the continuation of therapy, and all 9 patients are alive after 8 to 14 months.


Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
Sep 6, 1979·The New England Journal of Medicine·W Mueller, B Herrmann
Mar 21, 1981·British Medical Journal·R Y CalneR Williams
Jul 30, 1981·The New England Journal of Medicine·T E StarzlG P Schröter

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Jan 1, 1987·European Journal of Nuclear Medicine·H S ThomsenH Løkkegaard
Jan 1, 1985·Cardiovascular and Interventional Radiology·B A PorterR E Ward
May 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B D Kahan
Feb 1, 1986·European Journal of Clinical Investigation·H DieperinkE Kemp

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