99mTc-glucarate kinetics differentiate normal, stunned, hibernating, and nonviable myocardium in a perfused rat heart model.

European Journal of Nuclear Medicine and Molecular Imaging
D R OkadaRobert D Okada

Abstract

(99m)Tc-glucarate is an infarct-avid imaging agent. However, patients may have mixtures of normal, irreversibly injured, stunned, and hibernating myocardium. The purposes were to determine (99m)Tc-glucarate uptake and clearance kinetics in these four conditions, and its ability to determine the extent of injury. Twenty-two perfused rat hearts were studied: controls (n = 5), stunned (n = 5; 20-min no-flow followed by 5-min reflow), hibernating (n = 6; 120-min low flow at 4 ml/min), and ischemic-reperfused (n = 6; 120-min no-flow followed by reflow). (99m)Tc-glucarate was then infused. Tracer activity was monitored using a NaI scintillation detector and a multichannel analyzer. Creatine kinase, electron microscopy, and triphenyltetrazolium chloride determined viability. (99m)Tc-glucarate 10-min myocardial uptake was significantly greater in ischemic-reperfused (2.50 +/- 0.09) (cpm, SEM) than in control (1.74 +/- 0.07), stunned (1.68 +/- 0.11), and hibernating (1.59 +/- 0.11) (p < 0.05). Tracer retention curves for ischemic-reperfused were elevated at all time points as compared with the other groups. (99m)Tc-glucarate 60-min myocardial uptake was significantly greater in ischemic-reperfused (7.60 +/- 0.63) than in control (1.98 +...Continue Reading

References

Jul 1, 1997·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R S BeanlandsH Johansen
Jul 1, 1997·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·B A KhawJ Narula
Jan 6, 2001·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L L JohnsonB A Khaw
Apr 4, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·D R OkadaR D Okada
Oct 21, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Gerald JohnsonRobert D Okada

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Citations

Feb 23, 2019·Scientific Reports·Ben F BultenPaola A Erba
Feb 11, 2020·Journal of Drug Targeting·Dongjian ZhangJian Zhang
Nov 19, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Dongjian ZhangJian Zhang

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