(99m)Tc radiolabelling of Fe3O4-Au core-shell and Au-Fe3O4 dumbbell-like nanoparticles

Nanoscale
M Felber, R Alberto

Abstract

The development of nanoparticle-based dual-modality probes for magnetic resonance imaging (MRI) and positron emission tomography (PET) or single photon emission computed tomography (SPECT) is increasingly growing in importance. One of the most commonly used radionuclides for clinical SPECT imaging is (99m)Tc and the labelling of Fe3O4 nanoparticles with (99m)Tc was shown to be a successful strategy to obtain dual-modality imaging agents. In this work, we focus on gold containing magnetic nanomaterials. The radiolabelling of magnetic Fe3O4-Au core-shell and Fe3O4-Au dumbbell-like nanoparticles with the [(99m)Tc(CO)3](+) fragment is described. The key elements for this (99m)Tc labelling approach are novel coating ligands, consisting of an anchor for the Au surface, a polyethylene glycol linker and a strong chelator for the [(99m)Tc(CO)3](+) moiety.

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Citations

May 5, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xin TianYue Pan
Mar 24, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Edwin C PrattJan Grimm
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Mar 29, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Pallab Datta, Soumendranath Ray
Jan 26, 2021·Chemical Society Reviews·Juan PellicoRafael T M de Rosales

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