PMID: 11920543Mar 29, 2002Paper

99mTC-tetrofosmin scintigraphy in lung carcinoma staging and follow-up evaluations

Cancer
Gianfranco BuccheriAntonella Francini

Abstract

99mTC-tetrofosmin recently has emerged as a new radiopharmaceutical for cancer visualization. In this study, the authors have investigated, for the first time in a comprehensive way, its ability to assess lung carcinoma dissemination and progression. A 99mTC-tetrofosmin scan was incorporated into the pretreatment and posttreatment diagnostic workup of all lung carcinoma patients seen in a second referral institution for a province of 500,000 inhabitants during the years 1998 and 1999. Sixty-one patients, strongly suspected of lung carcinoma were photon-scanned; 21 of them were rescanned after completion of their front-line treatment. Eleven patients eventually underwent surgery, and 3 others underwent mediastinoscopy. Both planar and single photoemission computed tomography thoracic views were obtained. Images for the whole body also were acquired. All 57 patients whose lung carcinoma was pathologically confirmed showed accumulation of the radiotracer (100% sensitivity). However, three of the four nonmalignant lesions were also 99mTC-tetrofosmin positive. 99mTC-tetrofosmin scan was highly sensitive for the detection of the T0-T2 disease (97% sensitivity) and highly specific for the N0-N1 disease (83% specificity). In the 16 pat...Continue Reading

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Citations

Jul 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong-Xin ZhouYun-Qing Mei
Mar 22, 2005·Cancer Biotherapy & Radiopharmaceuticals·Bruno FattoriGiuliano Mariani
Feb 20, 2003·Clinical Nuclear Medicine·Mitsuyoshi HadaseHiroki Sugihara
Apr 19, 2003·Clinical Nuclear Medicine·Berna DegirmenciRecep Bekis

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