PMID: 8971855Oct 1, 1996Paper

99mTechnetium-stannous oxinate as marker of liposome formulations

Nuclear Medicine and Biology
M AlafandyF J Legros

Abstract

Liposomes associated with tin(II) dioxinate were prepared from egg yolk phosphatidylcholine and cholesterol as sterile and pyrogen-free multilamellar or unilamellar vesicles. Complexing of liposomal tin(II) dioxinate with 99mTc attained 98% of the added radioactivity. Thirty percent 99mTc were released during 24-h incubation in biological fluids. The absence of tin colloids seen by electron microscopy and the stability of liposomal phospholipid and tin(II) dioxinate during 72-h incubation at 37 degrees C in plasma and cerebrospinal fluid would allow safe and reliable scintigraphic liposome pharmacokinetic studies.

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Citations

Nov 18, 2000·Progress in Lipid Research·O C BoermanG Storm
Jun 6, 2000·Advanced Drug Delivery Reviews·P LavermanF H Corstens

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