PMID: 2510102Aug 1, 1989Paper

99Tcm-HMPAO SPET and cerebral blood flow: a study of CO2 reactivity

Nuclear Medicine Communications
M S ChokseyH A Crockard

Abstract

Single photon emission tomography (SPET) studies using 99Tcm-HMPAO are in widespread use in the functional imaging of cerebral blood flow (CBF). While qualitatively the images correlate well with other imaging modalities, there are doubts as to the quantitative accuracy of this method. In particular, the uptake and subsequent retention of 99Tcm-HMPAO in conditions of high flow is known to be nonlinear. In this study, we compared the quantitative retention of 99Tcm-HMPAO in eight subjects under conditions of normo- and hypercapnia. There was no significant increase, despite a mean rise of the end tidal pCO2 from 5.06 to 7.06 kPa, a stimulus that is known to provoke an 80-100% rise in CBF. We conclude that SPET studies with 99Tcm-HMPAO provide excellent qualitative images of the distribution of CBF, but that quantitative data in ml hg-1 min-1 must be interpreted with caution.

Citations

Jan 1, 1991·Neuroradiology·G J Hankey, C P Warlow
Apr 1, 1995·Italian Journal of Neurological Sciences·L FioraniR D'Alessandro
Aug 1, 1993·Pharmacology & Therapeutics·J A Madden
Jan 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·M S ChokseyH A Crockard
Apr 1, 1995·Seminars in Nuclear Medicine·C MessaP J Ell
Oct 1, 1993·The British Journal of Surgery·A R NaylorC V Ruckley
Sep 6, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Durval C Costa

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