Abstract
This phase I pilot study reports on (1) the safety and feasibility of 99Tc(m)-HL91, an amine oxime core radioligand that has shown oxygen dependent binding, and imaging; and (2) its usefulness for the visualization of local tumour recurrence of a biopsy proven squamous cell carcinoma of the head and neck (SCCHN) as compared to spiral computed tomogaphy (CT) and biopsy. Nine men (mean age 33 years, range 34-74 years) were prospectively included. For safety measurements, vital signs were recorded and serum chemical analysis carried out, with a complete blood cell count and urine analysis, and an ECG was performed prior to injection of 99Tc(m)-HL91 and repeated during the investigation. Single photon emission computed tomography (SPECT) scans of the head and neck, and of a standard, were performed at 2 h and 4 h post-injection of 740 MBq 99Tc(m)-HL91. Tumour-to-normal tissue background (T/N) ratios and percentage uptake were measured for all 99Tc(m)-HL91 scans. Spiral CT scans were obtained using a Somaton 4+ Siemens scanner within 1 week from the 99Tc(m)-HL91 scans. Based on CT and the 99Tc(m)-HL91 scan findings guided biopsies were performed. No adverse or subjective side effects were noticed. Vital signs, ECG findings, clinical...Continue Reading
References
Jan 1, 1992·British Journal of Cancer·M B ParliamentL I Wiebe
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·W J KohT W Griffin
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J D Chapman
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·P L Olive, R E Durand
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R C UrtasunC J Koch
May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·R A GatenbyG J Broder
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·W J KohK A Krohn
Mar 1, 1994·Archives of Otolaryngology--head & Neck Surgery·D J Terris, E P Dunphy
Oct 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M NordsmarkJ Overgaard
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D M BrizelM W Dewhirst
Mar 24, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J OvergaardK Jørgensen
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·A BeckerJ Dunst
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E LartigauM Guichard
Dec 16, 1998·The Laryngoscope·E C GabalskiD J Terris
Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·P StadlerM Molls
Jul 29, 1999·Nuclear Medicine Communications·M KooleR A Dierckx
Dec 1, 1953·The British Journal of Radiology·L H GRAYO C SCOTT
Citations
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Francis G Blankenberg, H William Strauss
Sep 12, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jiagao LüHua Wu
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Christophe Van de WieleRudi Andre Dierckx
Jan 28, 2012·Cancer Gene Therapy·B-F LeeA-L Shiau
Jul 1, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Gilles MeesChristophe Van de Wiele
Oct 3, 2003·Journal of Cellular Biochemistry·Francis G Blankenberg
Dec 17, 2008·The Kaohsiung Journal of Medical Sciences·Bi-Fang LeeLie-Hang Shen
Jun 14, 2005·Head & Neck·H L JanssenA C Begg
May 23, 2012·Critical Care Medicine·Sujatha Kannan, Michael V Johnston
Mar 13, 2018·Frontiers in Chemistry·Vincenzo MirabelloSofia I Pascu
Aug 16, 2001·Nuclear Medicine Communications·C Van De WieleUNKNOWN IMITT
Aug 29, 2018·International Journal of Molecular Sciences·Loredana G MarcuEva Bezak