A 1-minute full brain MR exam using a multicontrast EPI sequence

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Stefan SkareMathias Engström

Abstract

A new multicontrast echo-planar imaging (EPI)-based sequence is proposed for brain MRI, which can directly generate six MR contrasts (T1-FLAIR, T2-w, diffusion-weighted (DWI), apparent diffusion coefficient (ADC), T2*-w, T2-FLAIR) in 1 min with full brain coverage. This could enable clinical MR clinical screening in similar time as a conventional CT exam but with more soft-tissue information. Eleven sequence modules were created as dynamic building blocks for the sequence. Two EPI readout modules were reused throughout the sequence and were prepended by other modules to form the desired MR contrasts. Two scan protocols were optimized with scan times of 55-75 s. Motion experiments were carried out on two volunteers to investigate the robustness against head motion. Scans on patients were carried out and compared to conventional clinical images. The pulse sequence is found to be robust against motion given its single-shot nature of each contrast. For excessive out-of-plane head motion, the T1-FLAIR and T2-FLAIR contrasts suffer from incomplete inversion. Despite lower signal-to-noise ratio (SNR) and resolution, the 1-min multicontrast EPI data show promising correspondence with conventional diagnostic scans on patients. A 1 min m...Continue Reading

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Citations

Feb 9, 2019·Journal of Magnetic Resonance Imaging : JMRI·Daniel PolakKawin Setsompop
Apr 2, 2019·Journal of Magnetic Resonance Imaging : JMRI·Anna F DelgadoStefan Skare
Mar 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ola NorbeckStefan Skare
Mar 5, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel PolakKawin Setsompop
Sep 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rüdiger Stirnberg, Tony Stöcker
Sep 30, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Johan BerglundStefan Skare
Nov 5, 2019·Wellcome Open Research·James H ColeRobert Leech
Sep 19, 2020·Neuroradiology·Bryan A LanzmanKristen W Yeom
Apr 28, 2019·Current Oncology Reports·Alberto Falk DelgadoAnna Falk Delgado
May 21, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Berkin BilgicKawin Setsompop
Mar 26, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mary Kate ManhardKawin Setsompop
May 5, 2021·Journal of Magnetic Resonance Imaging : JMRI·Annika KitsAnna Falk Delgado
Aug 15, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel PolakStephen Cauley
Jan 1, 2022·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bryan CliffordStephen Cauley
Jan 6, 2022·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Serdest DemirJohn Conklin
Jan 12, 2022·Radiology·Joseph BenzakounCatherine Oppenheim

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