PMID: 109206Apr 1, 1979

A 10-year experience with topical mechlorethamine for mycosis fungoides: comparison with patients treated by total-skin electron-beam radiation therapy

Cancer Treatment Reports
E C VonderheidW C Johnson


A group of 243 patients with mycosis fungoides (MF) received treatment with topical applications of dilute aqueous solutions of mechlorethamine and/or systemic chemotherapy over the past 10 years. The likelihood of a complete and relapse-free remission and survival was found to correlate inversely to the magnitude of disease as denoted by a simple staging system. Although disease-free intervals of greater than 3 years have occurred thus far in 32 (13%) patients, the permanency of these remissions and the curability of disease remain uncertain because of the variability of disease progression characteristic of MF. Comparison of treatment results with those published on a large group of patients treated with total-skin electron-beam radiation therapy indicates that the chemotherapeutic approach to the treatment of MF is equally effective in promoting survival.

Related Concepts

Administration, Topical
Nitromin brand of mechlorethamine oxide
Mycosis Fungoides
Radiotherapy, Megavolt
Remission, Spontaneous
Sezary Syndrome
Malignant Neoplasm of Skin

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