A 10-Year Prospective Study of Bone Mineral Density and Bone Turnover in Males and Females With Type 1 Diabetes

The Journal of Clinical Endocrinology and Metabolism
Emma J HamiltonTimothy M E Davis

Abstract

In a previous community-based, cross-sectional study, males with type 1 diabetes (T1D) had lower bone mineral density (BMD) than did matched people without diabetes but females with T1D had normal BMD. To determine whether BMD in the males continued to decline, the neutral effect of T1D on BMD in females persisted, and whether temporal BMD changes reflected changes in bone turnover markers. Longitudinal observational study. Urban community. Forty-eight of the original 102 original cross-sectional study participants (20 males, 28 females) of mean age 42.0 years and median diabetes duration 14.6 years at baseline who were restudied a mean of 10.3 years later. BMD at total hip, femoral neck, lumbar spine (L1 to L4), and distal forearm. Biochemical bone turnover markers. After adjustment for age, body mass index (BMI), and renal function, there was no temporal change in BMD at the hip or forearm in the males (P ≥ 0.12), but lumbar spine BMD increased (P = 0.009). Females exhibited no statistically significant change in BMD in similar multivariable models that also included postmenopausal status, except a mild increase at the forearm (P = 0.046). Age- and sex-related changes in bone turnover markers paralleled those in general popul...Continue Reading

References

May 1, 1990·Journal of Internal Medicine·B MathiassenP Rødbro
Dec 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R Bucala, H Vlassara
Jul 1, 1994·Bone and Mineral·J M OlmosJ González-Macías
Feb 28, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B PiepkornJ Beyer
Dec 16, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T Miazgowski, S Czekalski
Dec 16, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A C LookerR Lindsay
Feb 29, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H K GenantN Khaltaev
Jul 27, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M M Campos PastorA G García-Cervigón
Apr 1, 2003·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Roger I PriceRichard L Prince
May 30, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Didier HansUNKNOWN International Society for Clinical Densitometry
Jun 17, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gert E Hein
Sep 5, 2006·Journal of Diabetes and Its Complications·Dimitrios J HadjidakisS A Raptis
Oct 28, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Vestergaard
Jan 16, 2007·European Journal of Internal Medicine·Steven BoonenDirk Vanderschueren
Apr 26, 2007·Diabetes Care·Susanne BechtoldHans Peter Schwarz
Jun 19, 2007·American Journal of Epidemiology·Mohsen JanghorbaniFrank B Hu
Dec 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Masahiro YamamotoToshitsugu Sugimoto
Jul 2, 2008·Diabetes Care·Lucy D MastrandreaTeresa Quattrin
Jan 8, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·E J HamiltonT M E Davis
Apr 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Ann V SchwartzUNKNOWN Health, Aging, and Body Composition Study
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Mar 25, 2011·Diabetes/metabolism Research and Reviews·Salila Kurra, Ethel Siris
May 1, 2012·International Journal of Epidemiology·Timothy M E DavisWendy A Davis
Jun 26, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D Leslie, L M Lix
Apr 8, 2014·Journal of Bone Metabolism·Ho-Sung Kim, Seoung-Oh Yang
Jun 23, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vikram V ShanbhogueKim Brixen
Aug 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y FanY Liu
Nov 6, 2015·European Journal of Endocrinology·F S HoughUNKNOWN IOF CSA Bone and Diabetes Working Group
Nov 4, 2016·Nature Reviews. Endocrinology·Nicola NapoliUNKNOWN IOF Bone and Diabetes Working Group
May 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Charlotte VerrokenBruno Lapauw
May 27, 2017·The Lancet. Diabetes & Endocrinology·Vikram V ShanbhogueAnne P Hermann
Oct 22, 2017·Diabetes Research and Clinical Practice·Emma J HamiltonTimothy M E Davis
Mar 17, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Paul GlendenningSamuel Vasikaran

❮ Previous
Next ❯

Citations

Jun 21, 2019·Journal of Diabetes·Jian-Min LiuUNKNOWN Chinese Society of Osteoporosis and Bone Mineral Research, the Chinese Society of Endocrinology, Chinese Diabetes Society, C
Sep 17, 2019·World Journal of Diabetes·Silvia Costantini, Caterina Conte
Oct 24, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S BallestaA Díez
Feb 2, 2021·Current Osteoporosis Reports·Julie Kristine KnudsenSuzette Sørensen
Jun 30, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Laura A Graeff-ArmasRobert R Recker
Aug 8, 2021·BMC Endocrine Disorders·Stefana Catalina BilhaMaria-Christina Ungureanu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.