A 10-year retrospective study of primary hyperparathyroidism in children

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
C-C LiJ Ouyang

Abstract

Primary hyperparathyroidism (PHPT) in children is thought to be extremely rare. The exact incidence is unknown and little is known of the characteristics of the disease. We reviewed our experience with PHPT to better characterize these patients. We carried out a retrospective study in 12 patients (age 9-16 years) who had surgical treatment between 2001 and 2011 in a single institution. There were 5 male subjects and 7 female subjects. The diagnosis of PHPT in pediatric patients is frequently delayed with an average time of 41 months. The main signs of PHPT were urinary and bone disorders, as well as non-specific signs. All patients had preoperative localization studies prior to operation. Combined using of neck sonography, MIBI-scintigraphy and CT and/or MRI, our patients had a positive predictive value of 100%. After operation, all patients were confirmed to have parathyroid adenoma. 1 patient had 2 adenomas, 1 of which was an ectopic adenoma located in the mediastinum. 9 patients experienced symptomatic hypocalcemia postoperatively. No patients had any serious long-term effects from parathyroidectomy at our institution. All patients were cured after removal of the parathyroid adenoma. No permanent complication was observed fo...Continue Reading

Citations

Mar 5, 2014·Case Reports in Pediatrics·Danielle L Gomez, Dorothy I Shulman
Jun 17, 2014·Seminars in Pediatric Surgery·Jocelyn F BurkeAnkush Gosain
Jul 6, 2013·The Journal of Surgical Research·Jocelyn F BurkeHerbert Chen
Oct 6, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Soham MukherjeeArunanshu Behera
Sep 20, 2012·Journal of the Chinese Medical Association : JCMA·Jeffrey Roizen, Michael A Levine
Apr 21, 2016·World Journal of Surgery·Naykky M Singh OspinaVictor M Montori
Sep 3, 2020·Annals of Pediatric Endocrinology & Metabolism·Youngseok SeoHo-Seong Kim
Jan 19, 2021·Medical Hypotheses·Kelly McKennaKourosh Parham
Apr 28, 2021·Pediatric Radiology·Hedieh KhalatbariMarguerite T Parisi
Apr 30, 2021·AACE Clinical Case Reports·Myrto Eleni FlokasLevon Agdere
May 4, 2021·Case Reports in Endocrinology·Gerdi TuliLuisa De Sanctis

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