A 10-year review of benign and malignant peripheral nerve sheath tumors in a single center: clinical and radiographic features can help to differentiate benign from malignant lesions

Plastic and Reconstructive Surgery
Dominic FurnissPaul Critchley

Abstract

Malignant peripheral nerve sheath tumors are rare, and their aggressive nature mandates treatment in specialist centers. In contrast, benign peripheral nerve sheath tumors are common and are treated by a variety of specialist surgeons, including plastic surgeons. The authors aimed to detect features in the clinical presentation of peripheral nerve sheath tumors that point toward a diagnosis of malignant peripheral nerve sheath tumor and therefore prompt referral to a specialist center. All histologically diagnosed primary peripheral nerve sheath tumors from January of 1995 to December of 2004 were identified from histopathology records. Notes were reviewed and analyzed with regard to symptoms, signs, radiology, electrophysiology, surgery, and pathology. Statistical comparisons used Fisher's exact test and the Mann-Whitney test. During the study period, 32 cases of malignant peripheral nerve sheath tumor in 30 patients were treated. Factors in the clinical evaluation that significantly predicted the presence of malignant peripheral nerve sheath tumor included site, large size, depth in relation to the deep fascia, short duration of symptoms, and pain. Magnetic resonance imaging and computed tomography were sensitive and specific...Continue Reading

References

Apr 1, 1978·AJR. American Journal of Roentgenology·J F Holt
May 1, 1992·Histopathology·M C DakinJ M Theaker
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·W W WongL L Gunderson
Sep 1, 1999·American Journal of Medical Genetics·J M Woodruff
May 16, 2002·Journal of Medical Genetics·D G R EvansA Moran
Sep 10, 2003·Neurology·Joachim M BaehringTracy T Batchelor
Nov 17, 2004·European Journal of Radiology·M PilavakiA Drevelengas

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Citations

Oct 20, 2009·Expert Reviews in Molecular Medicine·Daniela KatzDina Lev
Aug 28, 2012·Journal of Clinical Neuromuscular Disease·Jennifer A TracyP James B Dyck
Aug 4, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Geir TryggvasonMarlan R Hansen
May 22, 2010·AJR. American Journal of Roentgenology·Junji WasaNaoki Ishiguro
Mar 11, 2010·Clinical Oral Investigations·George João Ferreira do NascimentoLélia Batista de Souza
Sep 2, 2014·Journal of Ultrasound·Vasileios RafailidisDimitrios Rafailidis
Feb 7, 2012·The British Journal of Radiology·T HyodoK Kito
Oct 4, 2011·Seminars in Ultrasound, CT, and MR·Rebecca Stein-Wexler
Sep 3, 2010·The Journal of Hand Surgery·Sylvan E Clarke, Robert A Kaufmann
Jan 12, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Robert A Pearl, Greg O'Toole
Nov 18, 2008·Neurosurgery Clinics of North America·Kimberly K AmramiRobert J Spinner
Nov 18, 2008·Neurosurgery Clinics of North America·Jurrit J HofDavid R Haynor
Sep 2, 2015·Neurosurgical Focus·Manfred SchmidtOskar C Aszmann
Aug 18, 2009·Otolaryngologia polska. The Polish otolaryngology·Małgorzata PotockaEwa Izycka-Swieszewska
Feb 4, 2011·Foot & Ankle International·Jaime A CarvajalH Thomas Temple
Nov 18, 2009·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Tristan Barrett, Owen J Arthurs
Jan 14, 2020·Neurosurgery·Roberto J Perez-RomanAllan D Levi
Jun 23, 2018·Head and Neck Pathology·Faraj M AlotaibyIndraneel Bhattacharyya
Jun 20, 2020·European Journal of Radiology·Alexandra S GersingKlaus Woertler

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