A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

IEEE Journal of Solid-state Circuits
Marco BalliniAndreas Hierlemann

Abstract

To advance our understanding of the functioning of neuronal ensembles, systems are needed to enable simultaneous recording from a large number of individual neurons at high spatiotemporal resolution and good signal-to-noise ratio. Moreover, stimulation capability is highly desirable for investigating, for example, plasticity and learning processes. Here, we present a microelectrode array (MEA) system on a single CMOS die for in vitro recording and stimulation. The system incorporates 26,400 platinum electrodes, fabricated by in-house post-processing, over a large sensing area (3.85 × 2.10 mm(2)) with sub-cellular spatial resolution (pitch of 17.5 μm). Owing to an area and power efficient implementation, we were able to integrate 1024 readout channels on chip to record extracellular signals from a user-specified selection of electrodes. These channels feature noise values of 2.4 μVrms in the action-potential band (300 Hz-10 kHz) and 5.4 μVrms in the local-field-potential band (1 Hz-300 Hz), and provide programmable gain (up to 78 dB) to accommodate various biological preparations. Amplified and filtered signals are digitized by 10 bit parallel single-slope ADCs at 20 kSamples/s. The system also includes 32 stimulation units, whi...Continue Reading

Citations

Nov 28, 2017·Nature Communications·David TsaiKenneth L Shepard
Jan 30, 2018·IEEE Transactions on Biomedical Circuits and Systems·David TsaiKenneth L Shepard
Jul 12, 2018·Journal of Neurophysiology·Brian D AllenEdward S Boyden
Sep 11, 2017·Pflügers Archiv : European journal of physiology·Meng HuangManfred Lindau
May 24, 2019·Frontiers in Cellular Neuroscience·Vishalini EmmeneggerAndreas Hierlemann
Sep 27, 2019·Frontiers in Cellular Neuroscience·Torsten BullmannUrs Frey
Sep 24, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·M BirkholzR Scholz
Sep 22, 2015·Frontiers in Neural Circuits·Justin P KinneyEdward S Boyden
Nov 24, 2016·Journal of Materials Science. Materials in Medicine·Eric LeclercAgnès Tixier-Mita
Aug 11, 2017·Biomicrofluidics·Katharina WalczuchKatrin Bui-Göbbels
Jul 5, 2016·Frontiers in Neuroscience·Jeffrey R NaughtonMichael J Naughton
Jan 2, 2017·Microsystems & Nanoengineering·John P SeymourEuisik Yoon
Oct 26, 2018·Frontiers in Physiology·Marta K LewandowskaAnna Rostedt Punga
May 21, 2019·Frontiers in Neuroscience·Vijay ViswamAndreas Hierlemann
Mar 29, 2019·Frontiers in Neuroscience·Silvia RonchiAndreas Hierlemann
Jan 23, 2015·Frontiers in Neuroscience·Marie Engelene J ObienUrs Frey
Oct 31, 2019·Electrophoresis·Marvin SchwarzIordania Constantinou
Jul 10, 2020·Scientific Reports·Ryan P BadmanMichelle D Wang
Nov 11, 2020·ELife·Alessio P BuccinoMatthias H Hennig
Jan 28, 2021·Micromachines·Csaba ForroGabriella Panuccio
Feb 3, 2021·Micromachines·Leslie DonoghuePalaniappan Sethu
May 27, 2021·Nature Communications·Mohammadali SharifshazilehGiacomo Indiveri
Jun 26, 2021·Analytical Chemistry·Serge G Lemay, Taghi Moazzenzade
Jul 31, 2021·Frontiers in Neuroscience·Norberto Pérez-Prieto, Manuel Delgado-Restituto

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