A 12-month study of the effects of oral zidovudine on neurodevelopmental functioning in a cohort of vertically HIV-infected inner-city children

AIDS
M NozyceY St Louis

Abstract

To examine the effects of oral zidovudine on the neurodevelopmental functioning of HIV-infected children. Oral zidovudine was administered to 54 symptomatic children with vertically transmitted HIV infection (Centers for Disease Control and Prevention class P2). All children were recruited from an inner-city pediatric HIV/AIDS outpatient clinic and ranged in age from 2 months to 12 years and 11 months (mean age, 3 years) at entry. Neurodevelopmental functioning, height and weight, and lymphocyte subpopulation data were ascertained for all the children pretherapy, and 6 and 12 months post-therapy initiation. Analysis of the 6- and 12-month post-initiation drug data found no significant change in neurodevelopmental functioning. Height and weight percentiles remained the same or improved in the majority of children. CD4+ cell counts declined over the treatment period with CD4+ counts < 500 x 10(6)/l observed in 15% of the children pre-therapy, and 33% after 1 year. In contrast with previously published data, the present study observed no improvement in neurodevelopmental functioning in HIV-infected children treated with oral zidovudine.

Citations

Mar 1, 1996·Bulletin of Mathematical Biology·D Kirschner, G F Webb
Jan 1, 1996·Molecular Medicine Today·S DewhurstS M Fine
Aug 1, 1997·Perceptual and Motor Skills·E G FrankA Kuchuk
Apr 1, 1997·The Annals of Pharmacotherapy·S T MeltonS N Ghaemi
Oct 31, 2000·Scandinavian Journal of Infectious Diseases·V RosenfeldtA Paerregaard

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