A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Hyo-Suk LeeByung Chul Yoo

Abstract

Clevudine is a nucleoside analog with an unnatural beta-L configuration. In a phase I/II clinical trial, once daily doses ranging from 10 to 200 mg for 28 days were well tolerated, and produced significant antiviral activity. The present study was conducted to assess the degree and durability of the antiviral response to 12 weeks of clevudine treatment, and to investigate its safety and tolerability. A total of 98 patients with HBeAg-positive chronic hepatitis B were randomized to placebo (n=32), 30-mg clevudine (n=32), and 50-mg clevudine (n=34) groups. Patients were followed up after 12 weeks of treatment for a further 24 weeks off-therapy. Median serum hepatitis B virus DNA reductions from baseline at week 12 were 0.20, 4.49, and 4.45 log10 copies/mL in the placebo, 30-mg clevudine, and 50-mg clevudine groups, respectively (P < .0001). Posttreatment antiviral activities were sustained, with 3.32 and 2.99 log10 reductions at week 12 off-therapy and 2.28 and 1.40 log10 reductions at week 24 off-therapies in the 30- and 50-mg clevudine groups, respectively. Median serum alanine aminotransferase (ALT) levels decreased markedly from baseline during clevudine treatment and were maintained below the upper limit of normal throughout...Continue Reading

References

Feb 1, 1996·Antimicrobial Agents and Chemotherapy·S Balakrishna PaiY C Cheng
Dec 11, 1997·The New England Journal of Medicine·W M Lee
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y F LiawC M Chu
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N W LeungUNKNOWN Asia Hepatitis Lamivudine Study Group
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Yun-Fan Liaw
Feb 28, 2003·The New England Journal of Medicine·Patrick MarcellinUNKNOWN Adefovir Dipivoxil 437 Study Group
Sep 16, 2003·Journal of Hepatology·Nadia Alatrakchi, Margaret James Koziel
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick MarcellinHyo-Suk Lee
Aug 7, 2004·Journal of Clinical Microbiology·Simon Siu-Man SumLinqi Zhang
Aug 17, 2005·Seminars in Liver Disease·Robert P Perrillo

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Citations

Feb 3, 2009·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Shaili Gupta, Frederick L Altice
Mar 22, 2008·American Journal of Therapeutics·Emilio Palumbo
Jan 2, 2007·Current Opinion in Infectious Diseases·Gail Matthews
Jan 17, 2013·World Journal of Gastroenterology : WJG·Suk Bae KimHeon Young Lee
Nov 16, 2006·Expert Opinion on Therapeutic Targets·Daniel YerlyAndreas Cerny
Oct 3, 2006·Expert Review of Anti-infective Therapy·Winita Hardikar, Kathleen B Schwarz
Mar 1, 2008·Expert Review of Clinical Pharmacology·Seng Gee Lim
Aug 20, 2008·Expert Opinion on Pharmacotherapy·Mark A FeitelsonEva Ping Lu
Nov 18, 2008·Expert Opinion on Investigational Drugs·Tarik AsselahPatrick Marcellin
Jan 12, 2010·Bioorganic & Medicinal Chemistry·Damodar JanmanchiSheau Farn Yeh
Sep 4, 2009·Journal of Fluorine Chemistry·Peng LiuChung K Chu
Nov 6, 2007·Clinics in Liver Disease·Albert D Min, Jules L Dienstag
Jul 7, 2007·Archives of Medical Research·Margarita PardoVicente Carreño
Jan 16, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B Keeffe, Patrick Marcellin
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byung Chul YooHyo-Suk Lee
May 3, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mari Inada, Osamu Yokosuka
Jul 25, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byung Chul YooHyo-Suk Lee
Dec 24, 2010·The Korean Journal of Internal Medicine·Hyeon Woong YangHong Su Kim
May 15, 2010·Journal of Hepatology·Won Young TakYoon Kyung Sohn
Jul 21, 2009·Journal of Hepatology·Byung Kook KimChang Hong Lee
Aug 12, 2009·Journal of Hepatology·Russell D Fleischer, Anna S F Lok
Mar 8, 2013·Bioorganic & Medicinal Chemistry·Damodar JanmanchiSheau Farn Yeh
Jan 3, 2009·The Korean Journal of Hepatology·Hyung Joon Yim
Aug 20, 2016·Gut and Liver·Eun Young ChoUNKNOWN Antiviral Resistance Study Group
Jul 1, 2010·The Annals of Pharmacotherapy·Lauren M HynickaPunam H Patel
Oct 14, 2014·World Journal of Gastroenterology : WJG·Chan Ran YouSeung Kew Yoon
Dec 8, 2015·World Journal of Gastroenterology : WJG·Sobia ManzoorJaved Ashraf
Jun 17, 2020·Antimicrobial Agents and Chemotherapy·Katherine E SquiresAbel De La Rosa
Dec 6, 2008·The Korean Journal of Hepatology·Kwan Sik LeeUNKNOWN Korean Association for the Study of the Liver Guideline Committee

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