A 12-Week Physical and Cognitive Exercise Program Can Improve Cognitive Function and Neural Efficiency in Community-Dwelling Older Adults: A Randomized Controlled Trial

Journal of the American Geriatrics Society
Shu NishiguchiTadao Tsuboyama


To investigate whether a 12-week physical and cognitive exercise program can improve cognitive function and brain activation efficiency in community-dwelling older adults. Randomized controlled trial. Kyoto, Japan. Community-dwelling older adults (N = 48) were randomized into an exercise group (n = 24) and a control group (n = 24). Exercise group participants received a weekly dual task-based multimodal exercise class in combination with pedometer-based daily walking exercise during the 12-week intervention phase. Control group participants did not receive any intervention and were instructed to spend their time as usual during the intervention phase. The outcome measures were global cognitive function, memory function, executive function, and brain activation (measured using functional magnetic resonance imaging) associated with visual short-term memory. Exercise group participants had significantly greater postintervention improvement in memory and executive functions than the control group (P < .05). In addition, after the intervention, less activation was found in several brain regions associated with visual short-term memory, including the prefrontal cortex, in the exercise group (P < .001, uncorrected). A 12-week physical...Continue Reading


Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Aug 10, 2000·Experimental Brain Research·J M Fuster
Aug 24, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·W C GrovesC G Lyketsos
Jun 20, 2003·The New England Journal of Medicine·Joe VergheseHerman Buschke
Dec 20, 2005·Lancet·Cleusa P FerriUNKNOWN Alzheimer's Disease International
Feb 17, 2006·Neurobiology of Aging·Kirk I EricksonArthur F Kramer
Sep 5, 2008·JAMA : the Journal of the American Medical Association·Nicola T LautenschlagerOsvaldo P Almeida
Nov 13, 2008·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Jannique G Z van UffelenWillem van Mechelen
Apr 28, 2009·Nature Neuroscience·Nikolaus KriegeskorteChris I Baker
Jul 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron BrookmeyerH Michael Arrighi
Aug 21, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle C CarlsonLinda P Fried
Apr 3, 2010·Biological Psychiatry·Francis Clément, Sylvie Belleville
Mar 29, 2011·Frontiers in Human Neuroscience·Claudia Voelcker-RehageUrsula M Staudinger
Jun 13, 2012·Geriatrics & Gerontology International·Flávia Gomes de Melo CoelhoLilian Teresa Bucken Gobbi
Jun 21, 2012·Nature Reviews. Neuroscience·Cheryl Grady
Mar 26, 2013·International Journal of Geriatric Psychiatry·Stephen ToddA Peter Passmore
Jun 28, 2013·Journal of Alzheimer's Disease : JAD·J Carson SmithMatthew D Verber
Jul 19, 2013·Current Translational Geriatrics and Experimental Gerontology Reports·Sylvie Belleville, Louis Bherer
Jul 23, 2013·Frontiers in Aging Neuroscience·Scott M HayesMieke Verfaellie
Jan 24, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephan HeinzelMichael A Rapp
Mar 14, 2014·Experimental Brain Research·Toshikazu Kawagoe, Kaoru Sekiyama

❮ Previous
Next ❯


Mar 30, 2016·BioMed Research International·Magdalena Hagner-DerengowskaJacek Budzyński
Nov 7, 2015·Journal of the American Medical Directors Association·Barbara J Messinger-RapportJulie K Gammack
Nov 20, 2016·British Journal of Sports Medicine·Cindy K BarhaTeresa Liu-Ambrose
Jul 19, 2018·Journal of the American Geriatrics Society·Kazuki UemuraHiroshi Okamoto
Mar 14, 2019·The Cochrane Database of Systematic Reviews·Nicola J GatesRobin Wm Vernooij
Mar 14, 2019·The Cochrane Database of Systematic Reviews·Nicola J GatesAnne Ws Rutjes
Mar 14, 2019·The Cochrane Database of Systematic Reviews·Nicola J GatesRobin Wm Vernooij
Feb 28, 2020·The Cochrane Database of Systematic Reviews·Nicola J GatesRobin Wm Vernooij
Aug 29, 2020·International Journal of Environmental Research and Public Health·Wei GuoBiye Wang
Dec 20, 2018·Brain Plasticity·Jill N Barnes, Adam T Corkery
Jun 30, 2019·The Australian Journal of Rural Health·Melissa T NottMichael Curtin
Jul 9, 2020·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Bettina WollesenKim Delbaere
Aug 28, 2020·Frontiers in Nutrition·Diana Zukas AndreottiElisa Mitiko Kawamoto
Sep 22, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Edward S BlissDean E Mills
Nov 23, 2017·Frontiers in Aging Neuroscience·Jamie L TaitRobin M Daly
Nov 22, 2018·Frontiers in Aging Neuroscience·Maki SuzukiKaoru Sekiyama
Sep 12, 2019·Frontiers in Neuroscience·Charlotte GreeneSandrine Thuret
May 11, 2019·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Rasmus Tolstrup LarsenHenning Langberg
Dec 24, 2019·Frontiers in Aging Neuroscience·Cindy K BarhaTeresa Liu-Ambrose
Apr 18, 2017·International Psychogeriatrics·Francesca NevianiMirco Neri
Aug 19, 2015·Medicine and Science in Sports and Exercise·Dawn P GillRobert J Petrella
Dec 20, 2018·Brain Plasticity·Cindy K Barha, Teresa Liu-Ambrose
May 24, 2020·International Journal of Environmental Research and Public Health·Patricia Alexandra García-GarroAgustín Aibar-Almazán
Jul 4, 2020·BMC Geriatrics·Monisha IngoldKaren P Y Liu
Jun 21, 2020·Current Cardiology Reports·David Sabgir, Joan Dorn

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.