PMID: 20099236Jan 26, 2010Paper

A 12-week, randomized, double-masked study of fixed combination latanoprost/timolol versus latanoprost or timolol monotherapy

European Journal of Ophthalmology
Paul PalmbergCanada and United States Fixed Combination Latanoprost/Timolol Study Group

Abstract

To evaluate the efficacy and safety of fixed combination latanoprost/timolol versus latanoprost or timolol monotherapy. This 12-week, randomized, double-masked study was designed to overcome potential shortcomings of previous trials. We enrolled 788 subjects with open-angle glaucoma or ocular hypertension treated with a beta-blocker for > or = 4 weeks before screening. After washout, 500 subjects with a baseline mean intraocular pressure (IOP) > or = 26 and < 37 mmHg were randomized to fixed combination latanoprost-timolol in the evening (n = 170), latanoprost monotherapy in the evening (n = 165), or timolol monotherapy in the morning (n = 165). At weeks 2, 6, and 12, each subject's IOP level was measured in triplicate at 8 AM (predose), 10 AM, and 4 PM in each eye. Adverse events were monitored throughout. The statistical superiority of the fixed combination for the 18 pairwise comparisons with the 2 monotherapies was evaluated (analysis of variance). RESULTS. The statistical superiority of the fixed combination was demonstrated at 7/9 time points versus latanoprost and 9/9 time points versus timolol. Mean diurnal IOP levels were similar at baseline but significantly lower with the fixed combination than with either monotherap...Continue Reading

References

Aug 15, 1993·American Journal of Ophthalmology·W C StewartG Sethuraman
May 1, 1993·American Journal of Public Health·J H GurwitzJ Avorn
Dec 28, 1999·American Journal of Ophthalmology·W C StewartJ A Stewart
Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group
Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Dec 18, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Norbert Pfeiffer, UNKNOWN European Latanoprost Fixed Combination Study Group
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Mar 22, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Robert M Feldman
Oct 2, 2003·Journal of Glaucoma·James C TsaiJames W Pichert
Jan 15, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anastasios G P KonstasWilliam C Stewart
Jul 13, 2005·Archives of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Nov 3, 2005·Ophthalmology·Michael DiestelhorstUNKNOWN European-Canadian Latanoprost Fixed Combination Study Group
Nov 15, 2006·Archives of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Dec 22, 2006·Expert Opinion on Drug Safety·Gábor Holló
Aug 10, 2007·American Journal of Ophthalmology·Alan L RobinTania S Marcic

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Citations

Dec 13, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Luciano QuarantaIrene Floriani
May 6, 2020·Vestnik oftalmologii·N I Kurysheva
Mar 18, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Françoise Brignole-BaudouinChristophe Baudouin
Apr 29, 2016·Expert Opinion on Pharmacotherapy·Anastasios G P Konstas, Gabor Holló
Feb 3, 2015·Expert Opinion on Drug Safety·Gábor Holló, Andreas Katsanos
Jun 29, 2013·Expert Opinion on Pharmacotherapy·Anastasios Gp KonstasMurat Irkec

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