A 14-bp functional deletion within the CMTM2 gene is significantly associated with litter size in goat

Theriogenology
Zihong KangChuanying Pan

Abstract

CKLF-like MARVEL transmembrane domain-containing 2 (CMTM2) plays an important role in animal reproduction, and abnormal CMTM2 expression leads to spermatogenesis disorders. This study was conducted to assess the role of CMTM2 in goat reproduction by investigating an insertion/deletion (indel) variation and its effect on litter size, and to reveal its functional mechanism. A 14-base pair (bp) indel was found at position -861 to -848 nt of the CMTM2 promoter in 1131 female Shaanbei white cashmere goats. Association analyses revealed that the 14-bp indel in dams was significantly correlated with the size of the first litter (P = 0.013), with the 14-bp deletion significantly decreasing litter size. Moreover, litter size at first kidding was significantly correlated with genotype frequencies (P = 0.019). Expression of the goat CMTM2 gene was detected in testes and ovaries. In male, CMTM2 was increased after the initiation of meiosis in the developing testis. In female, CMTM2 expression was higher in ovary from multiple prolific goats at first kidding compared to non-prolific goats. Moreover, both in testis after initiation of meiosis and in ovary, the homozygous 14-bp inserted genotype II was associated with increased CMTM2 expressi...Continue Reading

Citations

Nov 7, 2019·Animals : an Open Access Journal From MDPI·Xinyu WangXianyong Lan
Apr 17, 2020·Animals : an Open Access Journal From MDPI·Libang HeLei Qu
Jan 23, 2020·Animals : an Open Access Journal From MDPI·Yi BiXiaoyue Song
Feb 6, 2020·Animals : an Open Access Journal From MDPI·Zhen WangHaijing Zhu
Feb 28, 2020·Animals : an Open Access Journal From MDPI·Jiayang GaoBao Zhang
Apr 8, 2021·Animal Biotechnology·Yun PanFugui Jiang
Apr 23, 2021·Reproduction, Fertility, and Development·Yangyang BaiXianyong Lan
May 6, 2021·Animal Biotechnology·Hongying RenChuanying Pan

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