Apr 1, 1976

A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney

Proceedings of the National Academy of Sciences of the United States of America
H G OienF A Kuehl

Abstract

Examination of a soluble fraction derived from homogenates of rabbit kidney papilla revealed the existence of a 15-hydroxyprostaglandin dehydrogenase specific for A-type prostaglandins. Prostaglandins of the E- and F-series were not substrates for this enzyme. In agreement with published data, the 15-hydroxyprostaglandin dehydrogenase(s) derived from the kidney cortex were found to degrade all prostaglandins examined (PGE, PGF, PGA) in the presence of added cofactor NAD. Thus it is evident that in this species the kidney 15-hydroxyprostaglandin dehydrogenases are anatomically compartmentalized so that the papilla is able to metabpable of degrading E-, F-, and A-type prostaglandins by this metabolic pathway.

Mentioned in this Paper

Alcohol Oxidoreductases
Lung
Hydroxyprostaglandin Dehydrogenases
NADH
Prostaglandins A
Kidney
HPGD
Papilla of Tongue
Structure of Cortex of Kidney
Metabolic Pathway

About this Paper

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