PMID: 8954798Dec 1, 1996Paper

A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13

Genomics
T F WoodM P Sawicki

Abstract

Linkage analysis and loss of heterozygosity studies have shown that the gene responsible for the multiple endocrine neoplasia type-1 (MEN1) syndrome localizes to a small interval between D11S427 and D11S460 on chromosome 11q13. As an initial step to clone this tumor suppressor gene, our group is the first to map the MEN1 region physically using yeast artificial chromosome, bacterial artificial chromosome (BAC), and cosmid contigs. The 1.5-Mb high-resolution, contiguous map extends from PYGM to 300 kb telomeric of D11S460. Of this, the 1.2-Mb interval between PYGM and D11S460 is isolated in cosmids and BACs and will be useful for the development of genomic sequences and transcription maps of this important region. Nine new sequence-tagged sites (STS) are also characterized from this region. The physical map and the STSs will be valuable tools for the cloning of the MEN1 gene.

Citations

Jul 29, 1998·Journal of Internal Medicine·P KomminothG Klöppel
Jul 29, 1998·Journal of Internal Medicine
Aug 26, 2000·Genes, Chromosomes & Cancer·E S SrivatsanJ L Redpath
Nov 24, 1999·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·P Komminoth
Dec 9, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A ChidambaramM Dean

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