A 1.7-megabase sequence-ready cosmid contig covering the TSC1 candidate region in 9q34

Genomics
N HornigoldJ Wolfe

Abstract

The disease gene TSC1 has been genetically mapped to human chromosome region 9q34, in a 4-cM interval between the markers D9S149 and D9S114. Within this interval there is conflicting genetic evidence as to the finer localization of the gene. We have used finger-printing methods and hybridization to produce a 1.7-Mb overlapping clone map covering the TSC1 candidate region, with a single gap of 20 kb. We have localized 12 previously cloned genes and 17 genetic markers on this map and have confirmed the order of the genetic map. This deep set of overlapping clones is now ready to be used for candidate gene isolation, for transcription studies, or for sequencing.

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Citations

Mar 26, 2010·Expert Reviews in Molecular Medicine·Courtney PollardDan Theodorescu
Oct 18, 2005·Genetic Testing·M NellistA M W van den Ouweland
Jun 3, 1999·Oncogene·N HornigoldM A Knowles
Jun 2, 2000·Biochemical and Biophysical Research Communications·M H ModarressiJ Wolfe
Aug 8, 1997·Science·M van SlegtenhorstD J Kwiatkowski

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