A 17-year experience of abobotulinumtoxina in cervical dystonia

The International Journal of Neuroscience
Francisco Vivancos-MatellanoExuperio Diez-Tejedor

Abstract

To investigate the long-term efficacy and safety of a botulinum toxin type A (BoNT-A) for the treatment of cervical dystonia (CD). We conducted a retrospective chart review of patients with CD treated with abobotulinumtoxinA (Dysport™ 100-800 units [U] for injection) between 1993 and 2009 at the University Hospital "La Paz" (LPUH). Affected muscles were selected using electromyography (EMG). Thirty-seven patients were included in the study; most were female (62%) and had idiopathic CD (60%). Almost half (46%) of patients were diagnosed with the condition more than 10 years ago. The most common clinical presentations of CD were rotation (46%) and laterocollis (43%). On average, patients were treated with Dysport for 7 years (range: 1-17 years) and received 487 (range: 320 to 650) U over 15.9 (range: 1 to 40) injection cycles. Most (97%) patients maintained a response from treatment initiation to end of evaluation period. Overall, 70% of patients were taking concomitant oral medication. Dysport was generally well tolerated. Dysphagia was reported by 18.9% of patients, but this did not lead to discontinuation of Dysport treatment. These data confirm the long-term efficacy and safety of Dysport in CD over a period of up to 17 years.

Associated Clinical Trials

References

Apr 24, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·Y Ben-ShlomoUNKNOWN ESDE collaborative group
Mar 1, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel TruongGeoffrey L Sheean
Apr 20, 2007·Parkinsonism & Related Disorders·J JankovicC Bergeron
Sep 20, 2007·Physical Therapy·Beth E Crowner
Apr 9, 2008·Arquivos de neuro-psiquiatria·Carlos Henrique F CamargoLineu César Werneck
Mar 13, 2009·Neurological Research·B MohammadiK Kollewe
Dec 17, 2009·Expert Opinion on Pharmacotherapy·Leslie J Cloud, H A Jinnah
Apr 3, 2010·Parkinsonism & Related Disorders·Daniel TruongUNKNOWN Global Dysport Cervical Dystonia Study Group

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Citations

Dec 3, 2014·Clinical Neurology and Neurosurgery·Josef Finsterer, Gonzalo J Revuelta
Nov 7, 2017·Operative Neurosurgery·Thomas J Wilson, Robert J Spinner
May 10, 2017·Neurotoxicity Research·A R BentivoglioMartina Petracca
Dec 10, 2020·The International Journal of Neuroscience·Michał MarciniecKonrad Rejdak

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