A [17F]-fluoromethane PET/TMS study of effective connectivity

Brain Research Bulletin
F FerrarelliGiulio Tononi

Abstract

We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.

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Citations

Oct 12, 2005·Current Psychiatry Reports·Felipe Fregni, Alvaro Pascual-Leone
Sep 22, 2005·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Saxby PridmoreMark George
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Reto HuberGiulio Tononi
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Feb 9, 2006·Brain Research Bulletin·S K EsserG Tononi
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Mar 15, 2012·Neuropsychologia·Marcello ManigliaGianluca Campana
Aug 12, 2016·Frontiers in Human Neuroscience·Antonino NaroAngelo Quartarone
Apr 18, 2009·Anesthesia and Analgesia·Bishwanath KumarUsha K Misra

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