A 19-Gauge Histology Needle Versus a 19-Gauge Standard Needle in Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Solid Lesions: A Multicenter Randomized Comparison Study (GREATER Study)

Digestive Diseases and Sciences
Takuji IwashitaIchiro Yasuda

Abstract

The necessity of histological analysis is increasing. A 19-gauge histology needle (PC19) in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has recently been developed and has shown high yields of tissue acquisition and histological diagnosis. To compare the histological diagnostic yield in single-pass EUS-FNA for solid lesions using PC19 and a standard 19-gauge needle (EC19). Consecutive patients with solid lesions were enrolled and underwent one pass with each of PC19 and EC19 for EUS-FNA with the randomized order of the needles. The primary endpoint was the histological diagnostic accuracy. The secondary endpoints were the feasibility, yield of histological core, cytological and overall diagnostic accuracies, and adverse events. Subgroup analysis was performed for the optimal situation with PC19. Of the 115 patients, 110 underwent EUS-FNA and five were excluded. EUS-FNA was performed from the esophagus in four, stomach in 80, or duodenum in 26. The final diagnosis was malignancy in 100 and benign in 10. The feasibility was 98.2 and 97.3% with PC19 and EC19, respectively (p = 1.00). The rate of presence of a histological core and the histological, cytological, and overall diagnostic accuracies for PC19 versus EC...Continue Reading

References

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Citations

Dec 24, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Takuji IwashitaMasahito Shimizu
Jun 6, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shigetaka YoshinagaYutaka Saito
May 23, 2019·Endoscopic Ultrasound·Tiing Leong AngLai Mun Wang
Jan 28, 2021·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·José Celso ArdenghJosé Sebastião Dos Santos
Dec 4, 2020·World Journal of Gastrointestinal Endoscopy·Andrew ChanRajvinder Singh
Feb 22, 2021·Journal of Digestive Diseases·Tiing Leong Ang, Lai Mun Wang

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