PMID: 8947478Nov 15, 1996Paper

A 19 kDa protein secreted by the endometrium of the mare is a novel member of the lipocalin family

The Biochemical Journal
B CrossettF Stewart

Abstract

Large quantities of an unusual 19 kDa protein (p19) are secreted into the lumen of the uterus of the mare (Equus caballus) during the oestrous cycle and early pregnancy. p19 associates strongly with the acellular capsule that surrounds the young horse conceptus and is believed to be important in maintaining pregnancy. Here we report the complete cDNA sequence encoding p19, its expression patterns in horse tissues and a Southern blot analysis of the gene in horse DNA. The predicted amino acid sequence of the p19 cDNA demonstrated a signal peptide of 18 residues and a mature protein of 162 residues, giving a predicted molecular mass of 18.8 kDa for the secreted protein. Analysis of the predicted amino acid sequence showed that p19 belongs to the lipocalin family of proteins, which are classified on the basis of three conserved amino acid sequence motifs and an eight-stranded anti-parallel beta-barrel conformation. Overall, p19 was most similar to the mouse major urinary protein (MUP) lipocalins (30-34% identity). Secondary structural predictions and structural modelling using the MUP 1 crystal structure coordinates gave convincing evidence that the three-dimensional structure of p19 closely resembles that of the lipocalins. Howev...Continue Reading

Citations

Dec 5, 2015·Journal of Animal Science and Biotechnology·Christine Aurich, Sven Budik
May 20, 2000·Biology of Reproduction·A HerrlerF Stewart
Jul 11, 2008·Biology of Reproduction·Ellen Menkhorst, Lynne Selwood
Dec 17, 2016·The Journal of Reproduction and Development·Shingo HanedaKazuhiko Imakawa
Nov 18, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Katrien SmitsAnn Van Soom
Jul 21, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·B A QuinnK J Betteridge
Nov 15, 2018·Reproduction in Domestic Animals = Zuchthygiene·Shawn-Elizabeth MaloneyElizabeth L Scholtz
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·C D MacCalmanG T Chen
Jan 29, 2020·Reproduction, Fertility, and Development·Mariana Diel de AmorimM Anthony Hayes
Jun 22, 2018·Journal of Animal Science and Biotechnology·Hakhyun KaJisoo Han
Jan 23, 2021·International Journal of Molecular Sciences·Carmen AlmiñanaStefan Bauersachs
Nov 4, 2000·Biochimica Et Biophysica Acta·L Sawyer, G Kontopidis
Nov 26, 2018·Theriogenology·H B A BastosR C Mattos
Jun 8, 2021·Frontiers in Physiology·Lindsay Sawyer

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